Migration resistant, blood-compatible plasticized polyvinyl chloride for medical and related applications
Migration resistant, blood-compatible plasticized polyvinyl chloride for medical and related applications
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DOI：
10.1046/j.1525-1594.1998.06124.x
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发表时间：
1998-03-01
影响因子：
2.4
通讯作者：
Jayakrishnan, A
中科院分区：
文献类型：
--
作者：
Lakshmi, S;Jayakrishnan, A
增塑聚氯乙烯（PVC）虽然不是血液相容性聚合物，但却是全世界制造血袋和血液透析管的首选材料。PVC通常用邻苯二甲酸二（2-乙基己基）酯（DEHP）增塑，以赋予最终产品柔韧性和低温性能。DEHP属于一类被称为降血脂肝癌原的物质，它少量迁移到血液、血浆或血清等储存介质中，导致许多毒性作用。通过经典的威廉姆森醚合成反应，将聚乙二醇（PEG）接枝到柔性PVC表面，可显著改善柔性PVC的抗迁移性和血液相容性。该技术简单且用途广泛，足以为许多医疗应用生产血液相容性，抗迁移的PVC表面。该方法还可用于防止增塑剂从广泛用于食品包装的PVC保鲜膜和聚偏二氯乙烯膜中迁移。
Plasticized polyvinyl chloride (PVC), although not a blood-compatible polymer, is the material of choice for the manufacture of blood bags and hemodialysis tubing throughout the world. PVC is usually plasticized with di-(2-ethylhexyl phthalate) (DEHP) to impart flexibility and low temperature properties to the final product. DEHP belongs to a class of agents called hypolipidemic hepatocarcinogens, and it migrates in small quantities into the storage medium such as blood, plasma, or serum, resulting in a number of toxic effects. It has been shown that the migration resistance and blood compatibility of flexible PVC could be significantly improved by grafting polyethylene glycol (PEG), the most blood-compatible polymer known today, onto the surface of flexible PVC by the classical Williamson ether synthesis reaction. The technique is simple and versatile enough to produce blood-compatible, migration resistant PVC surfaces for many medical applications. The method may also find use for preventing plasticizer migration from PVC cling films and polyvinylidene chloride films used extensively in food packaging.