Estrogen: effects on normal brain function and neuropsychiatric disorders
Estrogen: effects on normal brain function and neuropsychiatric disorders
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DOI：
10.1080/13697130701598746
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发表时间：
2007-10-01
期刊：
影响因子：
2.8
通讯作者：
Murphy, D. G.
中科院分区：
文献类型：
--
作者：
Craig, M. C.;Murphy, D. G.
许多女性抱怨记忆和其他认知/情绪困难，有时与雌激素水平的变化有关。然而，雌激素发挥这些作用的生物学机制仍然知之甚少。雌激素治疗对健康女性和阿尔茨海默病患者认知和脑功能的影响是有争议的。在这里，我们回顾了在健康女性中，雌激素影响多巴胺能、血清素能和胆碱能系统以及对高级认知功能和情绪至关重要的大脑区域的证据。我们还将介绍最近在我们实验室进行的体内随机对照神经影像学实验的结果，该实验表明，在年轻女性和中年女性中：(1)卵巢功能的正常变化调节了脑功能；(2)卵巢激素的急性丧失增加了神经元膜的破坏；(3)卵巢功能的急性抑制与大脑记忆关键区域的激活减少有关。
Many women complain of memory and other cognitive/emotional difficulties at times that are associated with changes in estrogen levels. However, the biological mechanisms through which estrogen may exert these effects remain poorly understood. The effect of estrogen treatment on cognition and brain function in healthy women, and those with Alzheimer's disease, is controversial. Here we review the evidence that, in healthy women, estrogen affects the dopaminergic, serotonergic, and cholinergic systems, and brain regions crucial to higher cognitive function and mood. We will also present results from recent in vivo randomized-controlled neuroimaging experiments in our laboratory demonstrating that, in young females, and those in mid-life: (1) brain function is modulated by normal variation in ovarian function; (2) acute loss of ovarian hormones increases neuronal membrane breakdown; and (3) acute suppression of ovarian function is associated with reduced activation of brain regions critical to memory.