The pap operon of avian pathogenic Escherichia coli strain O1:K1 is located on a novel pathogenicity island
The pap operon of avian pathogenic Escherichia coli strain O1:K1 is located on a novel pathogenicity island
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DOI：
10.1128/iai.74.1.744-749.2006
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发表时间：
2006-01-01
影响因子：
3.1
通讯作者：
Nolan, LK
中科院分区：
文献类型：
--
作者：
Kariyawasam, S;Johnson, TJ;Nolan, LK
我们在禽致病性大肠杆菌O 1：K1株（APEC-O 1）中发现了一个56 kb的致病岛（派）。该派，称为派IAPEC-O 1，整合在邻近pheV tRNA基因的3'末端。它携带APEC（pap操纵子）的推定毒力基因，其它E. coli基因（tia和ireA），以及APEC-O 1特有的1.5-kb区域。聚唾液酸胶囊的生物合成所需的kps基因簇被映射到该派的下游位置。
We have identified a 56-kb pathogenicity island (PAI) in avian pathogenic Escherichia coli strain O1:K1 (APEC-O1). This PAI, termed PAI IAPEC-O1, is integrated adjacent to the 3' end of the pheV tRNA gene. it carries putative virulence genes of APEC (pap operon), other E. coli genes (tia and ireA), and a 1.5-kb region unique to APEC-O1. The kps gene cluster required for the biosynthesis of polysialic acid capsule was mapped to a location immediately downstream of this PAI.