A Functional Neuroimaging Case Study of Meares-Irlen Syndrome/Visual Stress (MISViS)
A Functional Neuroimaging Case Study of Meares-Irlen Syndrome/Visual Stress (MISViS)
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DOI：
10.1007/s10548-011-0212-z
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发表时间：
2012-07-01
期刊：
影响因子：
2.7
通讯作者：
Cummine, Jacqueline
中科院分区：
文献类型：
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作者：
Chouinard, Brea D.;Zhou, Crystal I.;Cummine, Jacqueline
本研究的目的是评估来自阅读研究中被诊断为Meares-Irlen综合征/视觉应激（MISViS）的参与者的数据。MISViS的特点是视觉扭曲和躯体问题，使用彩色滤光片进行补救。作者介绍了一项病例研究，提供了MISViS与对照组的描述性神经生物学比较。这项研究涉及11名英语语言使用者，他们参与了一项语言实验的行为和神经成像版本，实验中使用了不同比例的常规和例外单词。行为测量包括准确性和响应时间。使用1.5T Siemens Sonata MRI进行神经成像。MISViS参与者的数据从整个实验中删除，并作为案例研究进行分析。脉冲响应函数（IRF）和活性体素的百分比提取的四个区域的利益：BA 17，18，19，和中央后回（PG）和两个控制区域（BA 6和左BA 45）。结果表明，对照组和MISViS参与者在两个区域（BA6和PG）的IRF强度和四个区域（BA17，BA19，PG和BA6）的活性体素百分比之间存在显著差异。左侧BA45中任一关注变量均无显著差异。行为指标无显著差异。总之，我们的研究结果提供了第一个神经生物学描述的差异IRF强度和百分比的视觉和躯体感觉皮层的活动体素在语言实验与MISViS的参与者在没有偏头痛相比，控制。
The aim of this study is to evaluate the data from a participant in a reading study who had a diagnosis of Meares-Irlen syndrome/visual stress (MISViS). MISViS is characterised by visual distortions and somatic issues, which are remediated using coloured filters. The authors present a case study providing descriptive neurobiological comparisons of MISViS versus a control group. The study involved eleven English language speakers who participated in behavioural and neuroimaging versions of a language experiment with varied proportions of regular and exception words. Behavioural measures included accuracy and response times. Neuroimaging was conducted using a 1.5T Siemens Sonata MRI. The MISViS participant's data were removed from the overall experiment and analysed as a case study. Impulse response functions (IRFs) and percentage of active voxels were extracted from four regions of interest: BAs 17, 18, 19, and the postcentral gyrus (PG) and two control regions (BA6 and left BA45). The results indicated that significant differences existed between the control group and the MISViS participant for IRF intensity in two regions (BA6 and PG) and percentage of active voxels in four regions (BA17, BA19, PG, and BA6). No significant differences occurred in left BA45 for either variable of interest. No significant differences were found for behavioural measures. In conclusion, our findings offer one of the first neurobiological descriptions of differences in IRF intensity and percentage of active voxels in visual and somatosensory cortex during a language experiment for a participant with MISViS in the absence of migraine compared to controls.