ANALYSIS OF A MODEL FOR EXCITATION OF MYELINATED NERVE
ANALYSIS OF A MODEL FOR EXCITATION OF MYELINATED NERVE
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DOI：
10.1109/tbme.1976.324593
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发表时间：
1976-01-01
影响因子：
4.6
通讯作者：
MCNEAL, DR
中科院分区：
文献类型：
--
作者：
MCNEAL, DR
在文献中已经提出了很好的模型，这些模型将膜电位与横膜电流联系起来，并描述了动作电位沿着轴突的传播，包括有髓纤维和无髓纤维。然而，还没有一个适当的神经兴奋模型，它允许人们使用不与神经纤维直接接触的电极来计算神经纤维对于有限持续时间的脉冲的阈值。本文认为这个问题，并提出了一个模型的有髓神经的电特性，它描述了事件的时间过程中的刺激应用启动的动作电位。在所有节点的随时间变化的电流和电位可以从模型中计算，和强度-持续时间曲线可以确定为任意电极的几何形状，虽然只有单极电极的情况下，在本文中被认为是。结果表明，即使当刺激是一个恒定的电流脉冲，在节点处的膜电流随时间变化很大。由该模型计算得到的强度-时间曲线与已有的实验数据相吻合，该模型提供了阈值与纤维直径之间的定量关系，表明大直径纤维的选择性小于小直径纤维。
Excellent models have been presented in the literature which relate membrane potential to transverse membrane current and which describe the propagation of action potentials along the axon, for both myelinated and nonmyelinated fibers. There is not, however, an adequate model for nerve excitation which allows one to compute the threshold of a nerve fiber for pulses of finite duration using electrodes that are not in direct contact with the fiber. This paper considers this problem and presents a model of the electrical properties of myelinated nerve which describes the time course of events following stimulus application up to the initiation of the action potential. The time-varying current and potential at all nodes can be computed from the model, and the strength-duration curve can be determined for arbitrary electrode geometries, although only the case of a monopolar electrode is considered in this paper. It is shown that even when the stimulus is a constant-current pulse, the membrane current at the nodes varies considerably with time. The strength-duration curve calculated from the model is consistent with previously published experimental data, and the model provides a quantitative relationship between threshold and fiber diameter which shows there is less selectivity among fibers of large diameter than those of small diameter.