ASSOCIATION OF MATERNAL SYSTEMIC LUPUS-ERYTHEMATOSUS WITH CONGENITAL COMPLETE HEART-BLOCK
ASSOCIATION OF MATERNAL SYSTEMIC LUPUS-ERYTHEMATOSUS WITH CONGENITAL COMPLETE HEART-BLOCK
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DOI：
10.1056/nejm197712012972203
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发表时间：
1977-01-01
影响因子：
158.5
通讯作者：
NOONAN, JA
中科院分区：
文献类型：
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作者：
CHAMEIDES, L;TRUEX, RC;NOONAN, JA
患有播散性红斑狼疮的母亲所生的婴儿偶尔会出现短暂的母体疾病表现。在患有系统性红斑狼疮的母亲所生的 6 名患有先天性心脏传导阻滞的婴儿中，推测存在因果关系。对其中一名婴儿的传导系统进行的尸检研究表明，房室结胚胎发育有缺陷，纤维环异常厚，并且受到早期炎症变化的影响。其中两名婴儿患有心肌病，三名婴儿患有相关的先天性心脏病。
Infants born to mothers with disseminated lupus erythematosus occasionally have transient manifestations of the maternal disease. In 6 infants with congenital heart block born to mothers with systemic lupus erythematosus, a causative relation was postulated. In 1 of the infants a post-mortem study of the conduction system suggested faulty embryonic development of the atrioventricular node with an abnormally thick annulus fibrosus and the effects of early inflammatory changes. Two of the infants had a cardiomyopathy and 3 had associated congenital heart disease.