Cytopathologic diagnosis on joint lavage fluid for patients with temporomandibular joint disorders.
Cytopathologic diagnosis on joint lavage fluid for patients with temporomandibular joint disorders.
复制标题
颞下颌关节紊乱病患者关节灌洗液的细胞病理学诊断。
DOI：
10.1002/dc.23023
复制
发表时间：
2014
影响因子：
1.3
通讯作者：
Mikami Toshinari
中科院分区：
文献类型：
--
作者：
K. Iwasaki;M. Sasaki;Y. Kodama;N. Matsumoto;S. Kimura and Y. Sugiyama;Mikami Toshinari
颞下颌关节（TMJ）疾病（TMD）的诊断通常基于患者的临床表现和影像学检查的结果，然而，在TMJ的炎症过程的理解是困难的。此外，许多TMJ疾病类型具有共同的主要症状。因此，颞下颌关节疾病在早期可能被误诊为TMD。假设关节灌洗液的细胞病理学检查有助于从细胞方面解释TMD相关的炎症过程。本研究的目的是评估颞下颌关节灌洗液细胞病理学在TMD患者。本研究纳入了39例临床诊断为TMD的患者。记录患者的临床症状。收集44份TMJ灌洗液样本，采用细胞块组织阵列法制作石蜡包埋细胞切片。采用细胞病理学方法对颞下颌关节上关节腔进行细胞学诊断，并与临床症状进行对照。在44个分析的关节灌洗液中的22个中检测到细胞成分。细胞病理学结果与临床症状之间存在相关性。临床症状相似的患者关节冲洗液的细胞病理学和炎症状态也有不同程度的改变，提示对TMD患者关节冲洗液进行细胞病理学检查有助于从细胞水平了解TMJ内部的局部情况。细胞病理学诊断。2014;42：30-36.© 2013 Wiley Periodicals，Inc.
Temporomandibular joint (TMJ) disorders (TMD) are usually diagnosed based on the patient's clinical findings and the results of image investigations; however, understanding of the inflammatory process in TMJ is difficult. In addition, many of the TMJ disease types share common principal symptoms. Therefore, TMJ diseases in the early stage can be misdiagnosed with TMD. It is hypothesized that cytopathologic examination of the joint lavage fluids is useful in interpreting the TMD‐associated inflammatory process from a cellular aspect. The aim of this study was to assess the TMJ lavage fluid cytopathologically in TMD patients. Thirty‐nine patients, clinically diagnosed as TMD, were included in the present study. Clinical symptoms of the patients were recorded. Forty‐four samples of TMJ lavage fluid were collected and paraffin‐embedded cell sections were made by cell block tissue array method. Cytologic conditions in upper articular cavity of TMJ were cytopathologically diagnosed and were compared with the clinical symptoms of each patient. Cell components were detected in 22 of the 44 analyzed joint lavage fluids. There was a correlation between cytopathologic findings and clinical symptoms. Variety of cytopathology and inflammatory conditions in patients with similar clinical symptoms were also found. The results suggested that cytopathologic examination of the joint lavage fluids from TMD patients is helpful for gaining an understanding of the inner local conditions of TMJ at the cellular level. Diagn. Cytopathol. 2014;42:30–36. © 2013 Wiley Periodicals, Inc.