TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning
TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning
复制标题
DOI：
10.1016/j.bbrc.2007.07.009
复制
发表时间：
2007-09-14
影响因子：
3.1
通讯作者：
Tytgat, Jan
中科院分区：
文献类型：
--
作者：
Cuypers, Eva;Yanagihara, Angel;Tytgat, Jan
雪卡鱼中毒和神经毒性贝类中毒是不同的临床症状，其特征是胃肠道和神经系统紊乱，发生在食用某些含有零星存在于某些有毒海洋甲藻中的有毒聚醚化合物的珊瑚鱼和贝类之后。甘比尔醇和短尾毒素及其同源物的生物转化和生物蓄积被认为与这些“食物链疾病”的发病机制有关，而目前尚无有效的治疗方法。在这里，我们首次描述了甘比尔醇和短尾草毒素对 TRPV1 通道的强大作用，TRPV1 通道是热觉和痛觉的关键角色。我们的发现可能会带来有希望的新治疗干预措施。 (C) 2007 Elsevier Inc. 保留所有权利。
Ciguatera fish poisoning and neurotoxic shellfish poisoning are distinct clinical entities characterized by gastrointestinal and neurological disturbances, following the consumption of certain reef fish and shellfish containing toxic polyether compounds sporadically present in certain toxic marine dinoflagellates. The biotransformation and bioaccumulation of gambierol and brevetoxin, and their congeners, are believed to be involved in the pathogenesis of these "food-chain diseases", for which no effective treatments are available. Here, we describe for the first time the potent effect of gambierol and brevetoxin on TRPV1 channels, a key player in thermal and pain sensation. Our findings may lead to promising new therapeutic interventions. (C) 2007 Elsevier Inc. All rights reserved.