Osteoporosis in Children with Chronic Disease
Osteoporosis in Children with Chronic Disease
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DOI：
10.1159/000381045
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Ward, Leanne
中科院分区：
文献类型：
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作者：
Hogler, Wolfgang;Ward, Leanne
严重的儿童疾病及其治疗可引起骨质疏松症，表现为脊椎和非脊椎骨折、疼痛、骨骼畸形和暂时性甚至永久性的骨丢失。与成人相比，儿童的骨骼生长提供了恢复骨矿物质密度和重塑骨折椎体的巨大潜力，即使没有骨靶向治疗，只要骨骼健康威胁是短暂的，残余生长是足够的。在这里，我们概述了骨强度发展的原则和骨质疏松症的危险因素，由于各种儿科系统性疾病。我们还解释了为什么儿童骨质疏松症的诊断和监测方法已经从以骨密度为中心的重点转移到更多的功能评估。最后，我们讨论了儿童骨质疏松症的最佳治疗方案和目前的治疗方法。(C)2015 S. Karger AG，巴塞尔
Serious illness in children and its therapy can cause osteoporosis, manifesting as vertebral and nonvertebral fractures, pain, skeletal deformity and temporary or even permanent loss of ambulation. In contrast to adults, skeletal growth in children offers tremendous potential to recover bone mineral density and to reshape fractured vertebral bodies, even without bone-targeted therapy, provided that bone health threats are transient and residual growth is sufficient. Here, we outline the principles of bone strength development and the risk factors for osteoporosis due to various paediatric systemic illnesses. We also explain why the approach to the diagnosis and monitoring of childhood osteoporosis has moved away from a bone density-centric focus to a more functional assessment. Finally, we discuss the best candidates for and current approaches to the treatment of osteoporosis in children. (C) 2015 S. Karger AG, Basel