Motor and sensory characteristics of infantile nystagmus
Motor and sensory characteristics of infantile nystagmus
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DOI：
10.1136/bjo.86.10.1152
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发表时间：
2002-10-01
影响因子：
4.1
通讯作者：
Bjerre, A
中科院分区：
文献类型：
--
作者：
Abadi, RV;Bjerre, A
背景/目标：过去的研究已经探索了特定的运动和感觉特征与非神经性婴儿眼球震颤的特定类别之间的一些关联。本案例研究的目的是扩展这一机构的工作显着通过描述的趋势和协会发现在数据库中的224名受试者谁经历了广泛的临床和心理物理evaluations.Methods：224例婴儿眼球震颤的记录进行了检查，其中62%是白痴，28%白化病，10%表现出眼部异常。记录的变量包括年龄、遗传方式、出生史、眼球震颤表现、眼球震颤方向、波形类型、空间和时间无效区、头部姿势和点头、会聚、中央凹、眼球对准、屈光不正、视力、立体视锐度和视觉障碍。224例患者的年龄分布在1个月至71岁之间，平均年龄和众数分别为23（SD 16）岁和16-20岁。到目前为止，最常见的遗传模式被发现是常染色体显性遗传（n = 40），与眼球震颤被观察到的年龄为6个月的87%的样本（n = 128），139（62%）的224名受试者被归类为白痴，63（28%）的白化病，和22（10%）表现出眼部异常。174例（77.7%）眼震中出现共轭单平面水平振荡，32例（14.3%）眼震中出现扭转分量。先天性眼球震颤（CN）182例（81.2%），显性潜伏性眼球震颤（MLN）32例（14.3%），CN/MLN混合型10例（4.5%）。CN和MLN波形均与三个受试者组（白痴、白化病患者和眼部异常）中的任何一个均无关。MLN见于白痴和白化病患者，但最常见于眼部异常组。最常见的振荡是水平急动伴扩大中心凹（n = 49; 27%）。眼震振幅为0.3- 15.7度，频率为0.5 ~ 8Hz。周期性交替性眼震常见于白化病人。白化病患者的眼球震颤强度在统计学上并不显著高于特发性变态反应患者（p>0.01）。143名受试者中有105名（73%）在初始位置的± 10度范围内存在空间零点，尽管98名受试者（69%）采用了补偿性头部姿势。空间零区大于或等于正负20度的受试者总是采用恒定的头部姿势。38例（27%）有点头现象，213例中有133例（62.4%）有水平斜视，32例MLN患者中除1例外均为斜视。成人视力与中心凹期的持续时间和准确性密切相关，视力和立体视锐度明显优于对照组（P < 0.01）。
Background/aims: Past studies have explored some of the associations between particular motor and sensory characteristics and specific categories of non-neurological infantile nystagmus. The purpose of this case study is to extend this body of work significantly by describing the trends and associations found in a database of 224 subjects who have undergone extensive clinical and psychophysical evaluations.Methods: The records of 224 subjects with infantile nystagmus were examined, where 62% were idiopaths, 28% albinos, and 10% exhibited ocular anomalies. Recorded variables included age, mode of inheritance, birth history, nystagmus presentation, direction of the nystagmus, waveform types, spatial and temporal null zones, head postures and nodding, convergence, foveation, ocular alignment, refractive error, visual acuity, stereoacuity, and oscillopsia.Results: The age distribution of the 224 patients was between 1 month and 71 years, with the mean age and mode being 23 (SD 16) years and 16-20 years respectively. By far the most common pattern of inheritance was found to be autosomal dominant (n = 40), with the nystagmus being observed by the age of 6 months in 87% of the sample (n = 128), 139 (62%) of the 224 subjects were classified as idiopaths, 63 (28%) as albinos, and 22 (10%) exhibited ocular anomalies. Conjugate uniplanar horizontal oscillations were found in 174 (77.7%) of the sample, 32 (14.3%) had a torsional component to their nystagmus. 182 (81.2%) were classed as congenital nystagmus (CN), 32 (14.3%) as manifest latent nystagmus (MLN), and 10 (4.5%) as a CN/MLN hybrid. Neither CN nor MLN waveforms were related to any of the three subject groups (idiopaths, albinos, and ocular anomalies) MLN was found in idiopaths and albinos, but most frequently in the ocular anomaly group, The most common oscillation was a horizontal jerk with extended foveation (n = 49; 27%). The amplitudes and frequencies of the nystagmus ranged between 0.3-15.7degrees and 0.5-8 Hz, respectively, Periodic alternating nystagmus is commonly found in albinos. Albino subjects did not show a statistically significantly higher nystagmus intensity when compared with the idiopaths (p>0.01). 105 of 143 subjects (73%) had spatial nulls within plus or minus 10degrees of the primary position although 98 subjects (69%) employed a compensatory head posture. Subjects with spatial null zones at or beyond plus or minus 20degrees always adopted constant head postures. Head nodding was found in 38 subjects (27% of the sample), Horizontal tropias were very common (133 out of 2 13; 62.4%) and all but one of the 32 subjects with MLN exhibited a squint, Adult visual acuity is strongly related to the duration and accuracy of the foveation period, Visual acuity and stereoacuity were significantly better (p