Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex
Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex
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DOI：
10.1016/s0896-6273(03)00152-1
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发表时间：
2003-04-24
期刊：
影响因子：
16.2
通讯作者：
Svoboda, K
中科院分区：
文献类型：
--
作者：
Shepherd, GMG;Pologruto, TA;Svoboda, K
在关键时期的感觉剥夺可降低脊柱运动，并破坏大鼠桶皮层中2/3层神经元的接受场结构。为了确定可塑性的轨迹，我们使用了激光扫描光刺激，使我们能够快速映射脑切片中的心脏内突触连通性。第2/3层神经元在其突触前伴侣的空间分布中有所不同：平均而言，直接收到的桶上方的神经元与第4层输入相比，与隔离桶上的隔sapa上方相比。在被剥夺的皮层中发现了互补的连通性：隔s上方的神经元与中隔区域强烈耦合，而枪管区域之间的连通性和第2/3层之间的连通性降低。这些结果揭示了桶形和间隔电路之间的竞争相互作用，以建立精确的物质内电路。
Sensory deprivation during a critical period reduces spine motility and disrupts receptive field structure of layer 2/3 neurons in rat barrel cortex. To determine the locus of plasticity, we used laser scanning photostimulation, allowing us to rapidly map intracortical synaptic connectivity in brain slices. Layer 2/3 neurons differed in their spatial distributions of presynaptic partners: neurons directly above barrels received, on average, significantly more layer 4 input than those above the septa separating barrels. Complementary connectivity was found in deprived cortex: neurons above septa were now strongly coupled to septal regions, while connectivity between barrel regions and layer 2/3 was reduced. These results reveal competitive interactions between barrel and septal circuits in the establishment of precise intracortical circuits.