Enzyme histochemical and ultrastructural alterations in the brains of Friesian calves with GM1 gangliosidosis
Enzyme histochemical and ultrastructural alterations in the brains of Friesian calves with GM1 gangliosidosis
复制标题
患有 GM1 神经节苷脂沉积症的弗里斯兰小牛大脑中酶组织化学和超微结构的改变
DOI：
10.1007/bf00685324
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发表时间：
2004
影响因子：
12.7
通讯作者：
W. Donnelly
中科院分区：
文献类型：
--
作者：
B. Sheahan;W. Donnelly
本文描述了7头患有GM 1神经节苷脂病的小牛脑组织酶和超微结构的改变。神经元中氧化酶活性的降低伴随着酸性磷酸酶活性的增加。神经元和神经胶质细胞中存在膜状胞质小体。膜的周期为约5.5至6.0 nm。电子致密的，膜结合的包涵体存在于外周细胞。与其他物种的神经节苷脂沉积症的病变进行了比较。
SummaryHistoenzymic and ultrastructural alterations in the brains of seven calves with GM1 gangliosidosis are described. A decreased oxidative enzyme activity in neurons was accompanied by an increase in acid phosphatase activity. Membranous cytoplasmic bodies were present in neurons and glia. The periodicity of the membranes was about 5.5 to 6.0 nm. Electron-dense, membrane-bound inclusions were present in perithelial cells. The lesions were compared with those of gangliosidoses in other species.