Twelve-year survey (2001-2012) of the antimicrobial susceptibility of Streptococcus pneumoniae isolates from otorhinolaryngology clinics in Miyagi Prefecture, Japan
Twelve-year survey (2001-2012) of the antimicrobial susceptibility of Streptococcus pneumoniae isolates from otorhinolaryngology clinics in Miyagi Prefecture, Japan
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DOI：
10.1016/j.jiac.2014.07.014
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发表时间：
2014-11-01
影响因子：
2.2
通讯作者：
Katori, Yukio
中科院分区：
文献类型：
--
作者：
Ozawa, Daiki;Yano, Hisakazu;Katori, Yukio
简介：肺炎链球菌是引起耳鼻咽喉感染的最常见细菌之一，如急性中耳炎和上呼吸道感染。本小组对耳鼻喉科患者分离的肺炎链球菌的药敏谱进行了调查。材料与方法：2001年5月至2012年12月在宫城医学会卫生中心共检出肺炎链球菌41,069株。标本取自日本宫城县40家耳鼻喉科门诊的患者。采用肉汤微量稀释法测定8种抗菌药物的最低抑菌浓度（mic）。结果：0 ~ 2岁儿童青霉素MIC50值从2010年的1 μ g/ml降至2012年的0.06 μ g/ml；ABPC: 1 μ g/ml (2010) ~ 0.25 μ g/ml（2012）。耐青霉素肺炎链球菌（PRSP）在鼻漏标本中的流行率从2010年的35.2%下降到2012年的14.6%，在耳漏标本中的流行率从2010年的43.4%下降到2012年的14.3%。头孢类药物（头孢曲松和头孢地酮）和碳青霉烯类药物（帕尼培南）的敏感性在2010年后也有所改善。在研究期间，大环内酯类药物（克拉霉素）和林科胺类药物（克林霉素）的MIC50值在所有年龄组中都有所增加，直到2012年都出现了高水平的耐药性。在研究期间，对氟喹诺酮类药物（LVFX）的敏感性无明显变化。结论：2010年以后，日本宫城县肺炎链球菌对β -内酰胺类药物的敏感性有所改善。(C) 2014年，日本化疗学会和日本传染病学会。Elsevier Ltd.出版。版权所有。
Introduction: Streptococcus pneumoniae is one of the most common bacteria causing otorhinolaryngological infections, such as acute otitis media and upper respiratory tract infection. Our group surveyed the drug susceptibility profile of S. pneumoniae isolates from otorhinolaryngology patients.Materials and methods: A total of 41,069 S. pneumoniae isolates were detected at Miyagi Medical Association Health Center between May 2001 and December 2012. Specimens were obtained from patients at 40 otorhinolaryngology outpatient clinics in Miyagi Prefecture, Japan. The minimum inhibitory concentrations (MICs) of 8 antimicrobial agents were measured using the broth microdilution method according to Clinical and Laboratory Standards Institute guidelines.Results: In children aged 0-2 years old, the MIC50 values of penicillins decreased after 2010 (PCG: 1 mu g/ml (2010) to 0.06 mu g/ml (2012); ABPC: 1 mu g/ml (2010) to 0.25 mu g/ml (2012)). The prevalence of penicillin-resistant S. pneumoniae (PRSP) decreased from 35.2% (2010) to 14.6% (2012) in rhinorrhea specimens and from 43.4% (2010) to 14.3% (2012) in otorrhea specimens. Susceptibility to cephems (ceftriaxone and cefditoren) and carbapenems (panipenem) also showed improvement after 2010. For macrolides (clarithromycin) and lincosamides (clindamycin), MIC50 values increased in all age groups during the study period, and a high level of resistance was seen until 2012. There were no marked changes of susceptibility to fluoroquinolones (LVFX) during the study period.Conclusion: Improvement of susceptibility of S. pneumoniae to beta-lactams occurred after 2010 in Miyagi Prefecture, Japan. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.