ASTROCYTE MATURATION AND SUSCEPTIBILITY TO ISCHEMIA OR SUBSTRATE DEPRIVATION
ASTROCYTE MATURATION AND SUSCEPTIBILITY TO ISCHEMIA OR SUBSTRATE DEPRIVATION
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DOI：
10.1097/00001756-199212000-00026
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发表时间：
1992-12-01
期刊：
影响因子：
1.7
通讯作者：
YAGER, JY
中科院分区：
文献类型：
--
作者：
JUURLINK, BHJ;HERTZ, L;YAGER, JY
我们证明，未成熟的星形胶质细胞死亡时，基板是剥夺在氧气的存在下，比成熟的星形胶质细胞早得多。相比之下，成熟的星形胶质细胞比未成熟的星形胶质细胞死亡早得多时，基板是剥夺在没有氧气。这些观察结果与最近的发现很好地相关，即新生啮齿动物大脑更容易因缺乏底物而不是缺氧而受到损伤。不成熟星形胶质细胞在氧气存在下对底物剥夺敏感性的基础尚不清楚，但可能与细胞清除自由基的能力有关。
WE demonstrate that immature astrocytes die much earlier than mature astrocytes when substrate is deprived in the presence of oxygen. In contrast, mature astrocytes die much earlier than immature astrocytes when substrate is deprived in the absence of oxygen. These observations correlate well with the recent findings that the newborn rodent brain is more susceptible to damage from lack of substrate than from lack of oxygen. The basis for this susceptibility of immature astrocytes to substrate deprivation in the presence of oxygen is not clear, but perhaps is related to the ability of the cell to scavenge free radicals.