ELEVATED LEVELS OF ANTIBODIES TO EPSTEIN-BARR VIRUS-ANTIGENS IN SERA AND SYNOVIAL-FLUIDS OF PATIENTS WITH RHEUMATOID-ARTHRITIS
ELEVATED LEVELS OF ANTIBODIES TO EPSTEIN-BARR VIRUS-ANTIGENS IN SERA AND SYNOVIAL-FLUIDS OF PATIENTS WITH RHEUMATOID-ARTHRITIS
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DOI：
10.1172/jci110127
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发表时间：
1981-01-01
影响因子：
15.9
通讯作者：
HENLE, W
中科院分区：
文献类型：
--
作者：
ALSPAUGH, MA;HENLE, G;HENLE, W
在类风湿性关节炎（RA）患者和其他结缔组织疾病患者的配对血清和滑液中检测eb病毒（EBV）特异性抗原抗体的频率和水平；即系统性红斑狼疮、进行性系统性硬化症和骨关节炎。还对标本进行了ra相关核抗原抗体检测。与健康对照组相比，患者血清中抗体滴度升高的频率增加。320)对Epstein-Barr病毒衣壳抗原，相应增强（2- 3倍）几何平均滴度和抗体在高滴度的频率增加（.gtoreq）。10)，通常针对早期抗原复合体的限制性组分，很少针对弥漫性组分。ebv相关核抗原抗体水平在正常范围内。血清阳性RA患者（即类风湿因子阳性）抗体滴度的增强比非血清阳性RA患者更为明显。在系统性红斑狼疮和进行性系统性硬化症中也发现增强。RA相关核抗原抗体仅在血清阳性RA患者组（90%）中检测到频率增加，而在其他结缔组织疾病组中为8-15%，在健康对照中为6-8%。滑液抗体滴度等于或最多为血清抗体滴度的2倍。ebv特异性抗体水平在RA和OA患者中连续研究了6-10个月。确定疾病活动性参数并与抗体水平进行比较。在整个研究过程中，OA患者血清中的ebv特异性抗体保持不变并在正常范围内。虽然ebv特异性抗体在RA患者中经常升高，但它们也保持不变，除了3例患者显示4种抗体中的1种逐渐升高，这与疾病活动无关。
The frequency and levels of antibodies to Epstein-Barr virus (EBV)-specific antigens were determined in paired sera and synovial fluids from patients with rheumatoid arthritis (RA) and in sera from patients with other connective tissue diseases; i.e., systemic lupus erythematosus, progressive systemic sclerosis and osteoarthritis (OA). The specimens were also tested for the presence of antibodies to RA-associated nuclear antigen. Compared to healthy controls, the patients'' sera showed increased frequency of elevated antibody titers (.gtoreq. 320) to Epstein-Barr viral capsid antigen, a correspondingly enhanced (2- to 3-fold) geometric mean titer and an increased frequency of antibodies at elevated titers (.gtoreq. 10), usually to the restricted component and rarely the diffuse component of the early antigen complex. Levels of antibody to the EBV-associated nuclear antigen were within the normal range. Enhancement of antibody titers was more pronounced in seropositive RA patients (i.e., positive for rheumatoid factor) than in those who were not. Enhancement was also found in systemic lupus erythematosus and progressive systemic sclerosis. Antibody to RA-associated nuclear antigen was detected at an increased frequency only in the group of seropositive RA patients (90%), as compared to 8-15% in the other connective tissue diseases and 6-8% in healthy controls. The antibody titers in the synovial fluids equaled or were at most 2-fold > or < those in the sera. Levels of EBV-specific antibodies were studied serially over a period of 6-10 mo. in patients with RA and OA. Parameters of disease activity were determined and compared to antibody levels. EBV-specific antibodies in sera of OA patients remained constant and within normal limits throughout the study. Although EBV-specific antibodies were often elevated in RA patients, they also remained constant, with the exception of 3 patients who showed gradual increases in 1 of the 4 antibodies, which did not correlate with disease activity.