Human myoblast differentiation: Ca(2+) channels are activated by K(+) channels.
Human myoblast differentiation: Ca(2+) channels are activated by K(+) channels.
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人成肌细胞分化：Ca(2)通道被K()通道激活。
DOI：
10.1152/physiologyonline.2002.17.1.22
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
C. Bader
中科院分区：
文献类型：
--
作者：
L. Bernheim;C. Bader
在细胞分化的范例--人类成肌细胞融合中，我们研究了融合所必需的钙离子内流是如何被触发的。我们展示了新表达的Kir2.1K(+)通道如何通过其对膜电位的超极化作用，产生窗口钙(2+)电流(由α1HT型钙(2+)通道介导)，从而导致细胞内钙(2+)升高。
In a paradigm of cellular differentiation, human myoblast fusion, we investigated how a Ca(2+) influx, indispensable for fusion, is triggered. We show how newly expressed Kir2.1 K(+) channels, via their hyperpolarizing effect on the membrane potential, generate a window Ca(2+) current (mediated by alpha 1H T-type Ca(2+) channels), which causes intracellular Ca(2+) to rise.