Long-term effects of alcohol consumption in male and female rats
Long-term effects of alcohol consumption in male and female rats
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DOI：
10.1007/s12012-007-9002-y
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Yuzhakova, Milina
中科院分区：
文献类型：
--
作者：
Piano, Mariann R.;Geenen, David L.;Yuzhakova, Milina
乙醇对心肌影响的潜在性别差异存在差异。因此，本研究的目的是确定长期饮酒是否与雌性大鼠患扩张型心肌病（CM）有关，其次确定卵巢激素的缺乏是否会调节这种效应。成年雄性和雌性（n = 6-8/组）假手术和卵巢切除（OVX）Sprague-Dawley 大鼠接受 Lieber DeCarli 含乙醇（8% vol/vol）或对照液体饮食 8 个月。所有乙醇组均显示超声心动图证据表明存在心脏病；然而，与女性或女性 OVX 组相比，男性乙醇组中发现了更显着的乙醇引起的差异。此外，男性乙醇组的体内收缩力测量值显着降低，例如收缩压变化的最大导数和预负荷可复张每搏功。后壁和间隔壁厚度变化的模式和程度也存在明显的性别差异，男性乙醇组的后壁和间隔壁变薄程度更大。总之，与雄性大鼠相似，性腺完整的雌性大鼠和去卵巢雌性大鼠的长期乙醇消耗与扩张型心肌病的发生有关。
Discrepancies exist regarding potential sex differences in the effects of ethanol on the myocardium. Therefore, the aims of this study were to determine if long-term ethanol consumption was associated with the development of a dilated cardiomyopathy (CM) in female rats and, second, to determine if the absence of ovarian hormones modulated this effect. Adult male and female (n = 6-8/group) sham-operated and ovariectomized (OVX) Sprague-Dawley rats received the Lieber DeCarli ethanol-containing (8% vol/vol) or control liquid diet for 8 months. All ethanol groups showed echocardiographic evidence of a cardiornyopathy; however, more significant ethanol-elicited differences were found in the male ethanol group than in either the female or female OVX groups. In addition, the male ethanol group had significant reductions in in vivo measures of contractility, such as the maximum derivative of change in systolic pressure and preload recruitable stroke work. Sex differences were also apparent in the pattern and degree of posterior and septal wall thickness changes, in that the male ethanol group had more posterior and septal wall thinning. In conclusion, similar to male rats long-term ethanol consumption in gonad-intact and OVX female rats is associated with the development of a dilated cardiomyopathy.