Durability and correlates of vaccine protection against Zika virus in rhesus monkeys.
Durability and correlates of vaccine protection against Zika virus in rhesus monkeys.
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DOI：
10.1126/scitranslmed.aao4163
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发表时间：
2017-12-13
影响因子：
17.1
通讯作者：
Barouch DH
中科院分区：
文献类型：
--
作者：
Abbink P;Larocca RA;Visitsunthorn K;Boyd M;De La Barrera RA;Gromowski GD;Kirilova M;Peterson R;Li Z;Nanayakkara O;Nityanandam R;Mercado NB;Borducchi EN;Chandrashekar A;Jetton D;Mojta S;Gandhi P;LeSuer J;Khatiwada S;Lewis MG;Modjarrad K;Jarman RG;Eckels KH;Thomas SJ;Michael NL;Barouch DH
有效的寨卡病毒疫苗需要长期持久的保护。几种寨卡病毒候选疫苗已证明对非人灵长类动物具有保护作用，但这类研究通常涉及免疫高峰期接种疫苗后不久的寨卡病毒攻击。在这项研究中，我们表明，单次接种腺病毒载体疫苗，以及两次接种纯化灭活病毒疫苗，在接种后1年对恒河猴提供了强大的保护。相比之下，使用优化的DNA疫苗进行两次免疫接种，在免疫高峰时提供完全保护，但在1年后的保护效果下降，与中和抗体滴度下降到亚保护水平有关。这些数据将微中和日志滴度定义为2.0-2.1，作为该模型中持久保护免受ZIKV挑战所需的阈值。此外，我们的研究结果表明，单次接种疫苗至少可以在1年内保护恒河猴免受寨卡病毒的攻击。
An effective Zika virus (ZIKV) vaccine will require long-term durable protection. Several ZIKV vaccine candidates have demonstrated protective efficacy in nonhuman primates, but such studies have typically involved ZIKV challenge shortly following vaccination at peak immunity. In this study, we show that a single immunization with an adenovirus vector-based vaccine, as well as two immunizations with a purified inactivated virus vaccine, afforded robust protection against ZIKV challenge in rhesus monkeys at 1 year following vaccination. In contrast, two immunizations with an optimized DNA vaccine, which provided complete protection at peak immunity, resulted in reduced protective efficacy at 1 year that was associated with declining neutralizing antibody titers to sub-protective levels. These data define a microneutralization log titer of 2.0-2.1 as the threshold required for durable protection against ZIKV challenge in this model. Moreover, our findings demonstrate that protection against ZIKV challenge in rhesus monkeys is possible for at least 1 year with a single-shot vaccine.
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影响因子：
64.8
作者：
Larocca, Rafael A.;Abbink, Peter;Peron, Jean Pierre S.;Zanotto, Paolo M. de A.;Iampietro, M. Justin;Badamchi-Zadeh, Alexander;Boyd, Michael;Ng'ang'a, David;Kirilova, Marinela;Nityanandam, Ramya;Mercado, Noe B.;Li, Zhenfeng;Moseley, Edward T.;Bricault, Christine A.;Borducchi, Erica N.;Giglio, Patricia B.;Jetton, David;Neubauer, George;Nkolola, Joseph P.;Maxfield, Lori F.;De La Barrera, Rafael A.;Jarman, Richard G.;Eckels, Kenneth H.;Michael, Nelson L.;Thomas, Stephen J.;Barouch, Dan H.
通讯作者：
Barouch, Dan H.
影响因子：
30.5
作者：
Dejnirattisai W;Supasa P;Wongwiwat W;Rouvinski A;Barba-Spaeth G;Duangchinda T;Sakuntabhai A;Cao-Lormeau VM;Malasit P;Rey FA;Mongkolsapaya J;Screaton GR
通讯作者：
Screaton GR
DOI：
10.1056/nejmoa1602412
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brasil P;Pereira JP Jr;Moreira ME;Ribeiro Nogueira RM;Damasceno L;Wakimoto M;Rabello RS;Valderramos SG;Halai UA;Salles TS;Zin AA;Horovitz D;Daltro P;Boechat M;Raja Gabaglia C;Carvalho de Sequeira P;Pilotto JH;Medialdea-Carrera R;Cotrim da Cunha D;Abreu de Carvalho LM;Pone M;Machado Siqueira A;Calvet GA;Rodrigues Baião AE;Neves ES;Nassar de Carvalho PR;Hasue RH;Marschik PB;Einspieler C;Janzen C;Cherry JD;Bispo de Filippis AM;Nielsen-Saines K
通讯作者：
Nielsen-Saines K
影响因子：
82.9
作者：
Shan C;Muruato AE;Nunes BTD;Luo H;Xie X;Medeiros DBA;Wakamiya M;Tesh RB;Barrett AD;Wang T;Weaver SC;Vasconcelos PFC;Rossi SL;Shi PY
通讯作者：
Shi PY
影响因子：
82.9
作者：
Osuna CE;Lim SY;Deleage C;Griffin BD;Stein D;Schroeder LT;Omange RW;Best K;Luo M;Hraber PT;Andersen-Elyard H;Ojeda EF;Huang S;Vanlandingham DL;Higgs S;Perelson AS;Estes JD;Safronetz D;Lewis MG;Whitney JB
通讯作者：
Whitney JB