Cell kinetics in the study and treatment of head and neck cancer
Cell kinetics in the study and treatment of head and neck cancer
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头颈癌研究和治疗中的细胞动力学
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
F. Volterrani
中科院分区：
文献类型：
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作者：
R. Molinari;Aurora Costa;R. Silvestrini;F. Mattavelli;G. Cantù;F. Chiesa;F. Volterrani
每个能够自我繁殖的细胞都要经历一个由四个连续阶段组成的细胞周期（图1），每个阶段都有一系列生化事件的特征，这些事件为下一个阶段做准备，并由特定的酶控制。第一个是有丝分裂期(M)，由于在光学显微镜下可以在形态学上识别，因此人们很早就知道它。另一个特征阶段是细胞为复制而合成DNA的阶段。在这些阶段之间插入另外两个时间间隔：有丝分裂后（G1）和有丝分裂前（G2）阶段，其中G代表间隙。事实上，在这些阶段，RNA和蛋白质被合成，但生化事件尚未被很好地定义。无论正常组织还是肿瘤组织，S期、g2期和M期的持续时间都相当稳定，分别为8-30小时、1-2小时和30-90分钟。
Every cell able to reproduce itself passes through a cell cycle composed of four successive phases (Fig. 1), and each one is characterized by a series of biochemical events that prepare the following phase and that are governed by specific enzymes. The first one is the mitotic phase (M), which has been well known for a long time because it is morphologically identifiable under light microscopy. Another characteristic phase is that in which the cell synthesizes its DNA for replication (S). Between these phases two other time intervals are intercalated: a postmitotic (G1) and a premitotic (G2) phase, where G stands for gap. In fact, during these phases, RNA and proteins are synthesized, but biochemical events have not yet been well defined. In every tissue, either normal or neoplastic, the duration of the S phase, G2and M are quite constant, accounting respectively for 8–30 h, 1–2 h, and 30–90 min.