Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: Role of the ventral medial prefrontal cortex
Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: Role of the ventral medial prefrontal cortex
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DOI：
10.1523/jneurosci.3630-06.2006
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发表时间：
2006-12-20
影响因子：
5.3
通讯作者：
Maier, Steven F.
中科院分区：
文献类型：
--
作者：
Amat, Jose;Paul, Evan;Maier, Steven F.
先前对受主体行为控制的应激源的经历，会阻断后续暴露于机体无法行为控制的应激源时的典型行为后果。本实验探究了腹内侧前额叶皮质（mPFCv）在介导这种由控制的初始经历所产生的“免疫”或恢复力效应中的作用。在控制的初始经历时以及后来暴露于不可控应激时，用蝇蕈醇使mPFCv失活会阻断行为免疫。在初始可控应激时给予茴香霉素抑制mPFCv内的蛋白质合成也会阻断免疫，但在后来不可控应激时给予则没有效果。其他实验发现，控制的初始经历会阻断中缝背核中血清素能细胞在通常由不可控应激所产生的强烈激活，这为行为免疫提供了一种机制。此外，在初始可控应激源期间mPFCv的活动是这种效应发生所必需的。这些结果表明，mPFCv既需要处理有关应激源可控性的信息，也需要利用这些信息来调节对后续应激源的反应。而且，mPFCv可能是有关可控性信息的一个储存或可塑性位点。这些结果与其他领域探索mPFCv功能的近期研究一致。
Previous experience with stressors over which the subject has behavioral control blocks the typical behavioral consequences of subsequent exposure to stressors over which the organism has no behavioral control. The present experiments explored the involvement of the ventral medial prefrontal cortex ( mPFCv) in mediating this "immunizing" or resilience producing effect of an initial experience with control. Behavioral immunization was blocked by inactivation of the mPFCv with muscimol at the time of the initial experience with control, as well as at the time of the later exposure to uncontrollable stress. Inhibition of protein synthesis within the mPFCv by anisomycin also blocked immunization when administered at the time of the initial controllable stress but had no effect when administered at the time of the later uncontrollable stress. Additional experiments found that the initial experience with control blocks the intense activation of serotonergic cells in the dorsal raphe nucleus that would normally be produced by uncontrollable stress, providing a mechanism for behavioral immunization. Furthermore, mPFCvactivity during the initial controllable stressor was required for this effect to occur. These results suggest that the mPFCv is needed both to process information about the controllability of stressors and to utilize such information to regulate responses to subsequent stressors. Moreover, the mPFCv may be a site of storage or plasticity concerning controllability information. These results are consistent with recent research in other domains that explore the functions of the mPFCv.