Peripapillary and optic nerve head vessel density of glaucoma and healthy subjects from Afro-Caribbean and European descent: A pilot study.
Peripapillary and optic nerve head vessel density of glaucoma and healthy subjects from Afro-Caribbean and European descent: A pilot study.
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DOI：
10.1016/j.jfo.2021.07.010
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发表时间：
2021-12
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通讯作者：
L. Salazar-Quiñones;C. Yu-Wai-Man;A. de Antonio Ramirez;C. Mendez-Hernandez;A. Daas;J. García Feijóo
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作者：
L. Salazar-Quiñones;C. Yu-Wai-Man;A. de Antonio Ramirez;C. Mendez-Hernandez;A. Daas;J. García Feijóo
目的比较非裔加勒比人后裔（AD）和欧洲后裔（艾德）青光眼患者（所有、早期、中度和晚期）与健康受试者的视乳头周围和视神经乳头血管密度（PP-ONH VD）。对90名受试者的一只眼睛进行了评价，包括66名青光眼患者和24名健康受试者，他们使用SPECTRALIS®光学相干断层血管造影术（OCT-A）进行了PP-ONH VD成像。我们使用AngioTool 0.6 a版软件分析了浅表血管复合体。用散点图和斯皮尔曼rho相关系数（correlationcoefficient.ResultsAmong the healthy subjects，AD组的浅表PP-ONH VD [43.29±3.25%（mean±standard deviation）]低于艾德组（46.06±1.75%）（P= 0.016）。总体而言，在总AD和艾德青光眼患者之间或亚组分析中，浅表PP-ONH VD未显示任何显著差异（早期/中度/晚期）AD分别为32.73± 6.70%、37.11± 5.72%、32.48± 5.73%、27.76± 4.74%;艾德分别为33.94± 6.89%、38.52± 3.82%、35.56±4.18%、27.65± 6.31%，差异均无统计学意义（P> 0.05）。在AD和艾德青光眼患者中，血管密度和平均偏差之间建立了强有力的统计学显著相关性（r= 0.709和r= 0.704）结论AD患者视乳头周围和视神经乳头表面血管密度低于艾德患者，但在AD和艾德青光眼组（全部、早期、中度或晚期）之间没有发现显著差异。
PurposeTo compare the peripapillary and optic nerve head vessel density (PP-ONH VD) between glaucoma patients (all, early, moderated, and advanced) and healthy subjects of Afro-Caribbean descent (AD) and European descent (ED).MethodsThis was a cross-sectional study. One eye was evaluated in 90 subjects, including 66 glaucoma patients and 24 healthy subjects, who underwent PP-ONH VD imaging using SPECTRALIS® Optical Coherence Tomography Angiography (OCT-A). We analysed the superficial vascular complex using the AngioTool version 0.6 a software. The correlation between the PP-ONH VD and visual field mean deviation (MD) was evaluated using a scatter plot and Spearman's rho correlation coefficient.ResultsAmong the healthy subjects, the AD group had a lower superficial PP-ONH VD [43.29±3.25%(mean±standard deviation)] than the ED group (46.06±1.75%)(P= 0.016). Overall, superficial PP-ONH VD did not show any significant differences between the total AD and ED glaucoma patients or in the subgroup analyses (early/moderate/advanced)(AD: 32.73±6.70%, 37.11±5.72%, 32.48±5.73%, 27.76±4.74%, respectively; ED: 33.94±6.89%, 38.52±3.82%, 35.56±4.18%; 27.65±6.31%, respectively)(P> 0.05 for all). A strong, statistically significant correlation was established between vessel density and mean deviation among AD and ED glaucoma patients (r= 0.709 and r= 0.704, respectively)(P< 0.001 for both).ConclusionThis pilot study shows that healthy subjects of AD had lower peripapillary and optic nerve head superficial vessel density than healthy subjects of ED, but no significant differences were found between AD and ED glaucoma groups (all, early, moderate, or advanced).