Redox balance in the aging microcirculation: new friends, new foes, and new clinical directions.
Redox balance in the aging microcirculation: new friends, new foes, and new clinical directions.
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DOI：
10.1111/j.1549-8719.2011.00139.x
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Leeuwenburgh C
中科院分区：
文献类型：
--
作者：
Muller-Delp JM;Gurovich AN;Christou DD;Leeuwenburgh C
心血管衰老与血管内皮功能的下降有关。相当多的证据表明，年龄诱导的内皮依赖性血管舒张功能的损害是由于一氧化氮（NO·）可用性的减少。NO·可被活性氧（ROS）清除，特别是被超氧自由基（O2·−）清除，并且已证明ROS的年龄相关性增加有助于许多大动脉制备物中内皮依赖性血管舒张的减少。相反，新出现的数据表明，ROS可能在老化微血管内皮功能中发挥代偿作用。本文综述的主要目的是讨论文献中表明ROS在衰老微血管中作为重要信号分子发挥作用的报道。重点放在讨论过氧化氢（H2O2）和过氧亚硝酸盐（ONOO·−）在衰老微循环中的新作用。总体而言，动物模型中的现有数据表明，维持ROS的平衡对于成功的微血管老化至关重要。有限的工作，已进行调查的作用，ROS在人类微血管老化进行了讨论，并认为需要在老年人的ROS信号的未来调查。
Cardiovascular aging is associated with a decline in the function of the vascular endothelium. Considerable evidence indicates that age-induced impairment of endothelium-dependent vasodilation results from a reduction in the availability of nitric oxide (NO•). NO• can be scavenged by reactive oxygen species (ROS), in particular by superoxide radical (O2•−), and age-related increases in ROS have been demonstrated to contribute to reduced endothelium-dependent vasodilation in numerous large artery preparations. In contrast, emerging data suggest that ROS may play a compensatory role in endothelial function of the aging microvasculature. The primary goal of this review is to discuss reports in the literature which indicate that ROS function as important signaling molecules in the aging microvasculature. Emphasis is placed upon discussion of the emerging roles of hydrogen peroxide (H2O2) and peroxynitrite (ONOO•−) in the aging microcirculation. Overall, existing data in animal models suggest that maintenance in the balance of ROS is critical to successful microvascular aging. The limited work that has been performed to investigate the role of ROS in human microvascular aging is also discussed, and the need for future investigations of ROS signaling in older humans is considered.
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DOI：
10.1152/ajplung.00168.2009
发表时间：
2009-12-01
影响因子：
4.9
作者：
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DOI：
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发表时间：
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