Precision epidemiology for infectious disease control
Precision epidemiology for infectious disease control
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DOI：
10.1038/s41591-019-0345-2
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发表时间：
2019-02-01
期刊：
影响因子：
82.9
通讯作者：
Andersen, Kristian G.
中科院分区：
文献类型：
--
作者：
Ladner, Jason T.;Grubaugh, Nathan D.;Andersen, Kristian G.
基因组学和计算的进步正在改变生物系统的表征能力，研究人员现在准备在他们准备和应对传染病的方式上进行精确的重点转变。这包括使用基于基因组的方法为分子诊断和个体水平的治疗方案提供信息。此外，病原体基因组生成速度和粒度的进步提高了追踪和了解病原体传播的能力，从而可能改善人口一级公共卫生干预措施的设计和实施。在这一视角中，我们概述了推动传染病精确流行病学发展的几个趋势，以及它们对科学家应对疫情能力的影响。
Advances in genomics and computing are transforming the capacity for the characterization of biological systems, and researchers are now poised for a precision-focused transformation in the way they prepare for, and respond to, infectious diseases. This includes the use of genome-based approaches to inform molecular diagnosis and individual-level treatment regimens. In addition, advances in the speed and granularity of pathogen genome generation have improved the capability to track and understand pathogen transmission, leading to potential improvements in the design and implementation of population-level public health interventions. In this Perspective, we outline several trends that are driving the development of precision epidemiology of infectious disease and their implications for scientists' ability to respond to outbreaks.