MULTICYSTIC OVARIES DETECTED BY SONOGRAPHY IN CHILDREN WITH HYPOTHYROIDISM
MULTICYSTIC OVARIES DETECTED BY SONOGRAPHY IN CHILDREN WITH HYPOTHYROIDISM
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DOI：
10.1001/archpedi.1980.02130180046014
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发表时间：
1980-01-01
影响因子：
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通讯作者：
MACGILLIVRAY, MH
中科院分区：
文献类型：
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作者：
LINDSAY, AN;VOORHESS, ML;MACGILLIVRAY, MH
四个女孩长期原发性甲状腺功能减退症，其中3人有适度的性早熟，被发现有多囊卵巢时，盆腔超声评价。其中三名患者的卵巢病变在临床上并不明显。囊肿消退迅速甲状腺替代品。盆腔超声检查可以显示多囊卵巢发生在甲状腺功能严重减退的女孩比以前报道的更常见。基线血浆促黄体激素（LH）水平（4名女孩中有3名升高）与尿LH输出（低或正常）之间存在显著差异。血浆和尿促卵泡激素水平正常。接受促性腺激素释放激素输注测试的3名女孩中，有2名促性腺激素反应减弱，而第3名反应正常。激素数据不能解释卵巢囊性变化和性发育早期。
Four girls with long-standing primary hypothyroidism, 3 of whom had modest sexual precocity, were found to have multicystic ovaries when evaluated by pelvic sonography. The ovarian lesions were not evident clinically in three of the patients. The cysts regressed rapidly with thyroid replacement. The use of pelvic sonography may show that multicystic ovaries occur more frequently in profoundly hypothyroid girls than has been reported previously. There was a marked discrepancy between baseline plasma luteinizing hormone (LH) levels, which were elevated in 3 of 4 girls, and the urinary LH output, which was low or normal. Plasma and urinary follicle-stimulating hormone levels were normal. Two of 3 girls tested with luteinizing hormone-releasing hormone infusion had attenuated gonadotropin responses, while the 3rd reacted normally. Hormonal data do not provide an explanation for the cystic ovarian changes and early sexual development.