Presynaptic long-term depression at the hippocampal mossy fiber-CA3 synapse
Presynaptic long-term depression at the hippocampal mossy fiber-CA3 synapse
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DOI：
10.1126/science.273.5275.648
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发表时间：
1996-08-02
期刊：
影响因子：
56.9
通讯作者：
Takahashi, T
中科院分区：
文献类型：
--
作者：
Kobayashi, K;Manabe, T;Takahashi, T
突触强度的长时程增强（LTP）和长时程抑制（LTD）可能是大脑学习和记忆的基础。 LTP 的诱导发生在海马 CA1 区的突触后细胞中，但在 CA3 区则发生在突触前细胞中。 LTD 在 CA1 中也有很好的特征，但在 CA3 中则不然。对小鼠海马切片的低频刺激在杂乱的纤维-CA3突触处引起同突触LTD，这可能是通过激活代谢型谷氨酸受体在突触前诱导的。因此，杂乱的纤维-CA3突触的功效可以双向调节，这可能有助于神经元信息处理。
Long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength may underlie learning and memory in the brain. The induction of LTP occurs in postsynaptic cells in the hippocampal CA1 region but is presynaptic in CA3. LTD is also well characterized in CA1 but not in CA3. Low-frequency stimulation of mouse hippocampal slices caused homosynaptic LTD at the messy fiber-CA3 synapse, which may be induced presynaptically by activation of metabotropic glutamate receptors. Thus, the efficacy of messy fiber-CA3 synapses can be regulated bidirectionally, which may contribute to neuronal information processing.