Trendy e-cigarettes enter Europe: chemical characterization of JUUL pods and its aerosols
Trendy e-cigarettes enter Europe: chemical characterization of JUUL pods and its aerosols
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DOI：
10.1007/s00204-020-02716-3
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发表时间：
2020-03-18
影响因子：
6.1
通讯作者：
Luch, Andreas
中科院分区：
文献类型：
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作者：
Mallock, Nadja;Trieu, Hai Linh;Luch, Andreas
美国豆荚电子烟JUUL的受欢迎程度和高尼古丁含量引起了许多担忧。为了符合欧洲法律，最近上市的欧洲版本的液体中的尼古丁浓度被限制在20 mg/mL以下。通过技术调整，增加汽化，从而提高尼古丁的释放量，可能会规避这一限制。在这项研究中，我们比较了最初的欧洲版本，修改后的欧洲版本和原始的美国高尼古丁变体的蒸汽生成和尼古丁输送，使用机器vaping设置。此外，在气溶胶中定量苯甲酸和羰基化合物。此外，还对尼古丁、苯甲酸、丙二醇和甘油的浓度沿着JUUL电子烟液的密度和pH值进行了评估。虽然最初的欧洲版本没有补偿液体中的低尼古丁含量，但我们提供了改进的欧洲版本增加蒸发的证据。因此，每次抽吸的尼古丁释放量接近美国原始水平。值得注意的是，这与羰基化合物的产生增加无关。我们的数据表明，增强型欧洲版本和原始美国产品具有类似的成瘾性。
The popularity and the high nicotine content of the American pod e-cigarette JUUL have raised many concerns. To comply with European law, the nicotine concentration in the liquids of the European version, which has been recently released on the market, is limited to below 20 mg/mL. This limit can possibly be circumvented by technological adjustments that increase vaporization and consequently, elevate nicotine delivery. In this study, we compare vapor generation and nicotine delivery of the initial European version, a modified European version, and the original American high-nicotine variant using a machine vaping set-up. Additionally, benzoic acid and carbonyl compounds are quantified in the aerosol. Further, concentrations of nicotine, benzoic acid, propylene glycol, and glycerol, along with the density and pH value of JUUL e-liquids have been assessed. Whereas the initial European version did not compensate for the low nicotine content in the liquid, we provide evidence for an increased vaporization by the modified European version. As a consequence, nicotine delivery per puff approximates the American original. Notably, this is not associated with an increased generation of carbonyl compounds. Our data suggest a similar addictiveness of the enhanced European version and the original American product.