Contractility of seminiferous tubules as related to sperm transport in the male.
Contractility of seminiferous tubules as related to sperm transport in the male.
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与男性精子运输相关的生精小管的收缩性。
DOI：
10.3109/01485018108987539
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
R. Tesi
中科院分区：
文献类型：
--
作者：
L. Ellis;M. D. Groesbeck;C. Farr;R. Tesi
哺乳动物睾丸具有多种机制来推动生精小管中的不动精子通过睾丸网进入附睾。这些包括（a）睾丸囊和生精小管的收缩，以及（b）由于液体和电解质从细胞外空间主动输送到生精小管而导致的液体流经外泄管。液体和精子从睾丸的流出似乎与精子的排出密切相关。前列腺素 (PGF2 α) 和可能的催产素（并非所有物种都对催产素有反应）可能会导致液体排出量增加，这是由于囊膜收缩压缩和排出小管中的液体而导致的。生精管收缩不是由神经刺激引起的，而是与 PG 和环核苷酸的产生有关。它们在一定程度上受到雄激素的调节，并且与睾酮相比，肾小管对 5α-二氢睾酮的反应较小，这可以通过它们与雄激素结合蛋白的相互作用以及它们对 PG 合成的磷脂酶 A2 活性的作用来解释。
The mammalian testes have several mechanisms to propel the nonmotile spermatozoa in the seminiferous tubules through the rete testis into the epididymis. These include (a) contractions of the testicular capsule and the seminiferous tubules and (b) fluid flow through the excurrent ducts resulting from active transport of fluids and electrolyte into the seminiferous tubules from the extracellular space. The efflux of fluids and sperm from the testis appears to closely parallel spermiation. An increased output of fluid may result from prostaglandins (PGF2 alpha) and possibly oxytocin (not all species respond to oxytocin) as a result of capsular contractions compressing and expelling the fluid from the tubules. Seminiferous tubular contractions do not result from nervous stimulation but are linked to PGs and cyclic nucleotide generation. They are regulated to some extent by androgens and the lesser response of the tubules to 5 alpha-dihydrotestosterone compared to testosterone can be explained by their interaction with androgen binding protein and their action on phospholipase A2 activity for PG synthesis.