Prebeta-1 HDL in plasma of normolipidemic individuals: influences of plasma lipoproteins, age, and gender.
Prebeta-1 HDL in plasma of normolipidemic individuals: influences of plasma lipoproteins, age, and gender.
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发表时间：
1998-03
影响因子：
6.5
通讯作者：
P. O’Connor;Bernice R. Zysow;S. Schoenhaus;B. Ishida;S. Kunitake;J. Naya-Vigne;Philippe Duchateau;R. Redberg;Susan J. Spencer;Saralyn Mark;M. Mazur;David C. Heilbron;Robert B. Jaffe;M. Malloy;John P. Kane
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作者：
P. O’Connor;Bernice R. Zysow;S. Schoenhaus;B. Ishida;S. Kunitake;J. Naya-Vigne;Philippe Duchateau;R. Redberg;Susan J. Spencer;Saralyn Mark;M. Mazur;David C. Heilbron;Robert B. Jaffe;M. Malloy;John P. Kane
前-1 HDL是一种分子量约为67 kDa的血浆HDL分子，含有载脂蛋白a- i、磷脂和未酯化胆固醇。它参与了从外周组织中回收胆固醇的循环过程。在这个循环中，来自细胞的未酯化胆固醇被纳入前-1 HDL，为卵磷脂的胆固醇酯化提供底物：胆固醇酰基转移酶。随着酯化过程的进行，β -1前HDL被纳入具有α迁移性的较大HDL种类，并在胆固醇酯从α HDL颗粒转移到受体脂蛋白的过程中再生。因此，血浆中β -1前高密度脂蛋白的稳态水平反映了其产生和去除的主要代谢过程的相对效率。我们使用同位素稀释技术测量136例正常血脂个体（46 M, 90 F）血浆中β -1前HDL水平。前β -1 HDL作为载脂蛋白A-I的平均绝对浓度，女性为68 +/- 40 μ g/ml，男性为84 +/- 49 μ m/ml。pre -1 HDL在女性中占总载脂蛋白A-I的5.5% +/- 3.3%，在男性中占7.2 +/- 4.0%。pre -1 HDL的绝对分布和百分比分布都是高度不对称的，向较高的值倾斜。然而，这种偏差似乎不能归因于血浆胆固醇或甘油三酯水平，它们在人口样本中也存在偏差。β -1前高密度脂蛋白百分比与高密度脂蛋白胆固醇水平呈负相关（P < 0.0001），而β -1前高密度脂蛋白的绝对水平与载脂蛋白A-I呈正相关，与高密度脂蛋白胆固醇呈负相关（P < 0.0001）。多元线性回归分析显示年龄和性别的影响，但与除HDL外的脂蛋白含量无关。在所有模型中，较低水平的β -1 HDL与女性有关。
Prebeta-1 HDL is a molecular species of plasma HDL of approximately 67 kDa mass that contains apolipoprotein A-I, phospholipids, and unesterified cholesterol. It participates in a cyclic process involved in the retrieval of cholesterol from peripheral tissues. In this cycle, unesterified cholesterol from cells is incorporated into prebeta-1 HDL, providing a substrate for esterification of cholesterol by lecithin:cholesterol acyltransferase. Prebeta-1 HDL then becomes incorporated into larger HDL species of alpha mobility as esterification proceeds and is regenerated during the transfer of cholesteryl esters from alpha HDL particles to acceptor lipoproteins. Thus the steady state level of prebeta-1 HDL in plasma reflects the relative efficiencies of the major metabolic processes involved in its generation and removal. We have used an isotope dilution technique to measure prebeta-1 HDL levels in the plasmas of 136 normolipidemic individuals (46 M, 90 F). The mean absolute concentration of prebeta-1 HDL as apolipoprotein A-I was 68 +/- 40 microg/ml for women, and 84 +/- 49 m/ml for men. Prebeta-1 HDL represented 5.5 +/- 3.3% of total apolipoprotein A-I in women, and 7.2 +/- 4.0% in men. The distributions of both absolute and percent prebeta-1 HDL are highly asymmetric, with skew toward higher values. However, the skew appears not to be attributable to either plasma cholesterol or triglyceride levels which are also skewed in population samples. The percent prebeta-1 HDL was negatively correlated with HDL cholesterol levels (P < 0.0001), whereas absolute levels of prebeta-1 HDL were positively correlated with apolipoprotein A-I and negatively correlated with HDL cholesterol (P, for both, < 0.0001). Multiple linear regression analysis revealed effects of age and gender, but no association with lipoprotein fractions other than HDL. Lower levels of prebeta-1 HDL were associated with female gender in all models.