Role of rifampin for treatment of orthopedic implant-related staphylococcal infections - A randomized controlled trial
Role of rifampin for treatment of orthopedic implant-related staphylococcal infections - A randomized controlled trial
复制标题
DOI：
10.1001/jama.279.19.1537
复制
发表时间：
1998-05-20
影响因子：
120.7
通讯作者：
Ochsner, PE
中科院分区：
文献类型：
--
作者：
Zimmerli, W;Widmer, AF;Ochsner, PE
背景。-基于体外和体内观察，含利福平的方案能够治愈葡萄球菌植入物相关感染。然而，这一证据尚未得到对照临床试验的证实。评价利福平联合治疗与稳定骨科器械相关的葡萄球菌感染的临床疗效。1992年至1997年进行的随机、安慰剂对照、双盲试验。与瑞士的5名整形外科医生合作，在三级护理中心提供两项传染病服务。共有33例患者经培养证实与稳定骨科植入物相关的葡萄球菌感染，感染症状持续时间短（排除限制
Context.-Rifampin-containing regimens are able to cure staphylococcal implant-related infections based on in vitro and in vivo observations. However, this evidence has not been proven by a controlled clinical trial.Objective.-To evaluate the clinical efficacy of a rifampin combination in staphylococcal infections associated with stable orthopedic devices.Design.-A randomized, placebo-controlled, double-blind trial conducted from 1992 through 1997.Setting.-Two infectious disease services in tertiary care centers in collaboration with 5 orthopedic surgeons in Switzerland.Patients.-A total of 33 patients with culture-proven staphylococcal infection associated with stable orthopedic implants and with a short duration of symptoms of infection (exclusion limit