Pilot randomized, non-inferiority, cross-over trial of once-weekly vs. three times-weekly recombinant factor VIII prophylaxis in adults with severe haemophilia A.

Pilot randomized, non-inferiority, cross-over trial of once-weekly vs. three times-weekly recombinant factor VIII prophylaxis in adults with severe haemophilia A.
复制标题

对患有严重 A 型血友病的成人进行每周一次与每周三次重组因子 VIII 预防的试点随机、非劣效性交叉试验。

DOI:
10.1111/hae.13131
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发表时间:
2017
期刊:
Haemophilia : the official journal of the World Federation of Hemophilia
影响因子:
--
通讯作者:
Moore,CG
Moore,CG
中科院分区:
--
文献类型:
--
作者:
Ragni,MV;Yabes,JG;Fogarty,PF;Josephson,NC;Kessler,CM;Neff,AT;Raffini,L;Brummel-Ziedins,K;Moore,CG

文献摘要

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* Current affiliation for Dr. Fogarty is Pfizer, Inc., Collegeville PA; Dr. Josephson is Seattle Genetics, Inc., Bothell WA; Dr. Neff is Cleveland Clinic Foundation, Cleveland OH; and Dr. Moore is Carolinas HealthCare System, Charlotte NC. Author Contribution: MVR designed the study, obtained funding, enrolled subjects, interpreted the data, and wrote the manuscript. NCJ enrolled study subjects, contributed to study design, and reviewed the manuscript. PFF, CMK, ATN, and LR contributed to study design and reviewed the manuscript. JGY performed data analysis, interpreted the data, and reviewed the manuscript. CGM contributed to the design, interpreted the data, and reviewed the manuscript. KBZ performed the assays, interpreted the data, and edited the manuscript.