The Relationship between Glucose Excursion and Cognitive Function in Aged Type 2 Diabetes Patients
The Relationship between Glucose Excursion and Cognitive Function in Aged Type 2 Diabetes Patients
复制标题
DOI：
10.3967/0895-3988.2012.01.001
复制
发表时间：
2012-02-01
影响因子：
3.5
通讯作者：
Jia Wei Ping
中科院分区：
文献类型：
--
作者：
Zhong Yuan;Zhang Xiao Yan;Jia Wei Ping
目的有证据表明2型糖尿病（T2DM）与痴呆的风险增加有关，血糖变异性是糖尿病并发症的独立危险因素。方法对248例老年2型糖尿病（T2DM）患者进行为期3 d的动态血糖监测（CGMS），测定血糖波动幅度（法师）和每日血糖波动差值（MODD）。所有受试者均接受了一些公认的认知功能测试，包括简易精神状态检查（MMSE）。结果法师评分与MMSE评分呈负相关，MODD评分与MMSE评分呈负相关。多元线性回归分析显示，法师、MODD与MMSE呈负相关，且与年龄、性别、血糖控制、高血压、吸烟、冠心病史无关。血糖波动升高降低了MMSE评分，这反映了一般认知功能。因此，旨在控制血糖波动的治疗可能有利于维持老年T2DM患者的认知功能。
Objective Evidence suggests that type 2 diabetes (T2DM) is associated with an increased risk of dementia and that glucose variability is an independent risk factor for diabetic complications. This study investigated the relationship between glucose excursion and cognitive function in aged T2DM patients.Methods A total of 248 aged T2DM patients wore a continuous glucose monitoring system (CGMS) for 3 days in order to evaluate glucose excursion, including mean amplitude of glycemic excursions (MAGE) and mean of daily difference (MODD). All subjects were evaluated with a number of accepted cognitive function tests, including the mini-mental status examination (MMSE). The relationship between MAGE and MODD and performance on these cognitive tests was assessed.Results The MAGE and MMSE score were negatively correlated, likewise with the correlation between MODD and MMSE. Liner multivariate regression analysis showed that MAGE and MODD were also negatively related to MMSE independent of age, sex, glycennic control, hypertension, smoking, or coronary heart disease history.Conclusion Glucose excursion is related to cognitive function in aged T2DM patients. Elevated glucose excursion decreased the MMSE score, which reflects general cognitive function. Thus, therapy aimed at controlling glucose excursion may be beneficial for maintaining cognitive function in aged T2DM patients.