Cardiotonic effects of anthopleurin-A (AP-A), a polypeptide from a sea anemone, in dogs with a coronary artery stenosis.
Cardiotonic effects of anthopleurin-A (AP-A), a polypeptide from a sea anemone, in dogs with a coronary artery stenosis.
复制标题
DOI：
10.1016/0014-2999(85)90223-7
复制
发表时间：
1985-04
影响因子：
5
通讯作者：
G. Gross;D. Warltier;H. F. Hardman;S. Shibata
中科院分区：
文献类型：
--
作者：
G. Gross;D. Warltier;H. F. Hardman;S. Shibata
在冠状动脉左前降支严重狭窄的麻醉犬模型上，观察AP-A的正性肌力作用。以峰值正值dp/dt(mm Hg/S)和节段缩短%(%SS)作为收缩功能指标。AP-A(1.5-5.0μg/kg，静脉注射)在不改变心率、平均动脉压或心肌血流量的情况下，整体(dp/dt，1700±100~2650±250 mm Hg/S)和局部缺血区(%SS，6.7±1.7~13.7±1.5%)产生正性肌力作用。这些数据表明，AP-A在心力衰竭的治疗中可能是潜在的有用的。
The positive inotropic effect of AP-A was studied in anesthetized dogs with a severe stenosis of the left anterior descending coronary artery. Peak positive dP/dt (mm Hg/s) and % segment shortening (%SS) were used as indices of contractile function. AP-A (1.5–5.0 μg/kg, i.v.) produced positive inotropic effects globally (dP/dt, 1700 ± 100 to 2650 ± 250 mm Hg/s) and locally in the ischemic zone (%SS, 6.7 ± 1.7 to 13.7 ± 1.5%) without changing heart rate, mean arterial pressure or myocardial blood flow. These data suggest that AP-A may be potentially useful in the management of heart failure.