Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine.
Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine.
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DOI：
10.1111/bph.13505
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发表时间：
2016-07
影响因子：
7.3
通讯作者：
Sethi JK
中科院分区：
文献类型：
--
作者：
Grolla AA;Travelli C;Genazzani AA;Sethi JK
在这篇综述中，我们重点关注烟酰胺磷酸核糖转移酶（NAMPT）的分泌形式；细胞外 NAMPT (eNAMPT)，也称为前 B 细胞集落增强因子或内脂素。虽然细胞内 NAMPT 是控制 NAD 代谢的关键酶，但 eNAMPT 据报道可作为细胞因子发挥作用，在生理学和病理学中发挥多种作用。循环 eNAMPT 与多种代谢和炎症性疾病有关，包括癌症。由于肿瘤微环境中产生的细胞因子在癌症发病机制中发挥着重要作用，部分通过重新编程细胞代谢来实现，因此癌症免疫治疗的未来改进将需要更好地了解细胞因子作用与肿瘤生物学之间的相互作用。在这篇综述中，将讨论 eNAMPT 在癌症中的知识，重点关注其作为代谢因子的免疫代谢功能、其分泌、其作用机制以及在癌症微环境中的可能作用。
In this review, we focus on the secreted form of nicotinamide phosphoribosyltransferase (NAMPT); extracellular NAMPT (eNAMPT), also known as pre‐B cell colony‐enhancing factor or visfatin. Although intracellular NAMPT is a key enzyme in controlling NAD metabolism, eNAMPT has been reported to function as a cytokine, with many roles in physiology and pathology. Circulating eNAMPT has been associated with several metabolic and inflammatory disorders, including cancer. Because cytokines produced in the tumour micro‐environment play an important role in cancer pathogenesis, in part by reprogramming cellular metabolism, future improvements in cancer immunotherapy will require a better understanding of the crosstalk between cytokine action and tumour biology. In this review, the knowledge of eNAMPT in cancer will be discussed, focusing on its immunometabolic function as a metabokine, its secretion, its mechanism of action and possible roles in the cancer micro‐environment.