Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations.
Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations.
复制标题
DOI：
10.1038/s41598-018-33507-7
复制
发表时间：
2018-10-15
影响因子：
4.6
通讯作者：
Menni C
中科院分区：
文献类型：
--
作者：
Barrios C;Zierer J;Würtz P;Haller T;Metspalu A;Gieger C;Thorand B;Meisinger C;Waldenberger M;Raitakari O;Lehtimäki T;Otero S;Rodríguez E;Pedro-Botet J;Kähönen M;Ala-Korpela M;Kastenmüller G;Spector TD;Pascual J;Menni C
利用227个空腹血清代谢特征的靶向核磁共振波谱，我们在来自四个独立队列的926名2型糖尿病患者(T2D)和4838名非糖尿病患者中寻找新的肾功能代谢特征。我们进一步研究了代谢指标和肾功能的纵向变化以及与其他T2D微血管并发症的关系。在调整混杂因素和多重检测后，142个性状与肾小球滤过率(EGFR)相关：糖尿病组59个，非糖尿病组109个，重叠26个。在所有队列中，氨基酸甘氨酸和苯丙氨酸以及能量代谢产物柠檬酸和甘油与EGFR呈负相关，而丙氨酸、丙氨酸和丙酮酸在糖尿病患者(阳性)和非糖尿病患者(阴性)中表现出相反的相关性。此外，在所有队列中，不同脂蛋白亚类的甘油三酯含量与EGFR呈负相关，而高密度脂蛋白中的胆固醇、胆固醇酯(CE)和磷脂与较好的肾功能相关。相反，低密度脂蛋白中的磷脂和CES仅在T2D中与EGFR呈正相关，而高密度脂蛋白中的磷脂含量与EGFR在横断面和纵向上仅在非糖尿病患者中呈正相关。总之，我们提供了一个广泛的与肾功能相关的代谢特征清单，并确定了糖尿病和非糖尿病肾脏疾病之间的新的代谢差异。
Using targeted NMR spectroscopy of 227 fasting serum metabolic traits, we searched for novel metabolic signatures of renal function in 926 type 2 diabetics (T2D) and 4838 non-diabetic individuals from four independent cohorts. We furthermore investigated longitudinal changes of metabolic measures and renal function and associations with other T2D microvascular complications. 142 traits correlated with glomerular filtration rate (eGFR) after adjusting for confounders and multiple testing: 59 in diabetics, 109 in non-diabetics with 26 overlapping. The amino acids glycine and phenylalanine and the energy metabolites citrate and glycerol were negatively associated with eGFR in all the cohorts, while alanine, valine and pyruvate depicted opposite association in diabetics (positive) and non-diabetics (negative). Moreover, in all cohorts, the triglyceride content of different lipoprotein subclasses showed a negative association with eGFR, while cholesterol, cholesterol esters (CE), and phospholipids in HDL were associated with better renal function. In contrast, phospholipids and CEs in LDL showed positive associations with eGFR only in T2D, while phospholipid content in HDL was positively associated with eGFR both cross-sectionally and longitudinally only in non-diabetics. In conclusion, we provide a wide list of kidney function–associated metabolic traits and identified novel metabolic differences between diabetic and non-diabetic kidney disease.
登录
查看更多内容
DOI：
10.1161/atvbaha.116.307385
发表时间：
2016-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Apro J;Tietge UJ;Dikkers A;Parini P;Angelin B;Rudling M
通讯作者：
Rudling M
影响因子：
7.7
作者：
Floegel A;Stefan N;Yu Z;Mühlenbruch K;Drogan D;Joost HG;Fritsche A;Häring HU;Hrabě de Angelis M;Peters A;Roden M;Prehn C;Wang-Sattler R;Illig T;Schulze MB;Adamski J;Boeing H;Pischon T
通讯作者：
Pischon T
影响因子：
3.7
作者：
Kim JA;Choi HJ;Kwon YK;Ryu DH;Kwon TH;Hwang GS
通讯作者：
Hwang GS
影响因子：
3.8
作者：
Li, J;Ji, L
通讯作者：
Ji, L
影响因子：
5.3
作者：
Barrios, Clara;Pascual, Julio;Valdivielso, Jose M.
通讯作者：
Valdivielso, Jose M.