ON THE EVOLUTION OF RNA EDITING
ON THE EVOLUTION OF RNA EDITING
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DOI：
10.1016/0168-9525(93)90011-6
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发表时间：
1993-08-01
影响因子：
11.4
通讯作者：
GRAY, MW
中科院分区：
文献类型：
--
作者：
COVELLO, PS;GRAY, MW
术语“RNA编辑”涵盖改变RNA转录物的一级核苷酸序列与其编码DNA的一级核苷酸序列的各种过程。就像RNA剪接等其他分子遗传现象一样，RNA编辑的发现给分子生物学家带来了一个进化难题，因为RNA编辑的存在并没有提供明显的选择优势。基于RNA编辑活性和编辑位点的协同进化，提出了RNA编辑进化的三步模型，其中遗传漂变是RNA编辑进化的重要组成部分。该模型对已知形式的RNA编辑的影响进行了讨论
The term 'RNA editing' encompasses a variety of processes that change the primary nucleotide sequence of an RNA transcript from that of its encoding DNA. As in the case of certain other molecular genetic phenomena, for example RNA splicing, the discovery of RNA editing presented molecular biologists with an evolutionary puzzle, since the existence of RNA editing offers no obvious selective advantage. A three-step model for the evolution of RNA editing is proposed, based on the co-evolution of editing activity and editing sites, with genetic drift as an important component. The implications of this model for the known forms of RNA editing are discussed