Novel glucocorticoid antedrugs possessing a 21-(γ-lactone) ring
Novel glucocorticoid antedrugs possessing a 21-(γ-lactone) ring
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DOI：
10.1039/b200190j
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发表时间：
2002-01-01
期刊：
影响因子：
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通讯作者：
Procopiou, PA
中科院分区：
文献类型：
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作者：
Angell, RM;Biggadike, K;Procopiou, PA
制备了一系列在C21处带有γ-丁内酯的新的双烷衍生物，并作为糖皮质激素激动剂进行了测试。还测试了化合物在人血浆中的不稳定性，发现其被对氧磷酶快速水解为相应的羟基酸。
A series of novel pregnane derivatives bearing gamma-butyrolactones at C21 were prepared and tested as glucocorticoid agonists. The compounds were also tested for their lability in human plasma, and found to be rapidly hydrolysed by the enzyme paraoxonase to the respective hydroxyacids.