Reductive and oxidative transformations of the N-(cyanomethyl)oxazolidine system to expand the chiral pool of piperidines
Reductive and oxidative transformations of the N-(cyanomethyl)oxazolidine system to expand the chiral pool of piperidines
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DOI：
10.1002/ejoc.20040404
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发表时间：
2004-11-26
影响因子：
2.8
通讯作者：
Husson, HP
中科院分区：
文献类型：
--
作者：
François, D;Poupon, E;Husson, HP
已经利用两种新的反应来修饰含有手性、非外消旋N-（氰基甲基）恶唑烷系统的哌啶支架。首先研究了Raney镍介导的脱氰反应，然后使用高锰酸钾进行氧化过程以提供包括氧代哌啶酸衍生物的对映体纯内酰胺。((C)Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2004）
Two new reactions have been exploited to modify piperidine scaffolds containing the chiral, non-racemic N-(cyanomethyl)oxazolidine system. A Raney nickel mediated decyanation was studied first, followed by an oxidative process using potassium permanganate to furnish enantiopure lactams including oxopipecolic acid derivatives. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)