Antifungal immune reactivity in nasal polyposis
Antifungal immune reactivity in nasal polyposis
复制标题
DOI：
10.1128/iai.72.12.7275-7281.2004
复制
发表时间：
2004-12-01
影响因子：
3.1
通讯作者：
Romani, L
中科院分区：
文献类型：
--
作者：
Pitzurra, L;Bellocchio, S;Romani, L
由于真菌病因已被提出是严重鼻息肉病的基础，本研究旨在评估鼻息肉病局部抗真菌免疫反应性。为此，在有鼻症状、有无息肉病的患者和健康受试者中，评估了微生物定植、辅助性T细胞1 (Th1)/Th2细胞因子产生和toll样受体（TLR）表达的模式。结果表明，Th2反应性是鼻息肉患者的共同发现，无论是否存在微生物。在细菌和真菌定植的患者中，白细胞介素-10的产生升高，而在微生物定植的患者中，TLR2和TLR4的表达均局部受损。嗜酸性粒细胞和中性粒细胞在鼻息肉病中高度募集，对真菌的分生孢子和菌丝发挥有效的抗真菌作用，并受到TLR2或TLR4刺激的正调节。因此，效应细胞激活和失活信号之间的局部不平衡可能有助于真菌致病性和鼻息肉病局部免疫反应性的表达。
As a fungal etiology has been proposed to underlie severe nasal polyposis, the present study was undertaken to assess local antifungal immune reactivity in nasal polyposis. For this purpose, microbial colonization, along with the pattern of T helper 1 (Th1)/Th2 cytokine production and Toll-like receptor (TLR) expression, was evaluated in patients with nasal symptoms and with and without polyposis and in healthy subjects. The results show that Th2 reactivity was a common finding for patients with nasal polyposis regardless of the presence of microbes. The production of interleukin-10 was elevated in patients with bacterial and, particularly, fungal colonization, while both TLR2 expression and TLR4 expression were locally impaired in microbe-colonized patients. Eosinophils and neutrophils, highly recruited in nasal polyposis, were found to exert potent antifungal effector activities toward conidia and hyphae of the fungus and to be positively regulated by TLR2 or TLR4 stimulation. Therefore, a local imbalance between activating and deactivating signals to effector cells may likely contribute to fungal pathogenicity and the expression of local immune reactivity in nasal polyposis.