Effects of chronic DHEA treatment on central and peripheral reproductive parameters, the onset of vaginal opening and the estrous cycle in female rats
Effects of chronic DHEA treatment on central and peripheral reproductive parameters, the onset of vaginal opening and the estrous cycle in female rats
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DOI：
10.3109/09513590.2016.1163672
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发表时间：
2016-03
影响因子：
2
通讯作者：
T. Iwasa;T. Matsuzaki;A. Tungalagsuvd;M. Munkhzaya;Mayila Yiliyasi;Takeshi Kato;A. Kuwahara;M. Irahara
中科院分区：
文献类型：
--
作者：
T. Iwasa;T. Matsuzaki;A. Tungalagsuvd;M. Munkhzaya;Mayila Yiliyasi;Takeshi Kato;A. Kuwahara;M. Irahara
新生儿和/或青春期前的雄激素环境影响成年期的性成熟和生殖功能。然而，慢性脱氢表雄酮（DHEA）治疗对生殖功能的影响尚未完全阐明。因此，本研究对慢性DHEA治疗大鼠的生殖表型和参数进行了评估。慢性DHEA治疗的大鼠（出生后23-12周龄）阴道开口提前，表明DHEA治疗促进性成熟。此外，经dhea处理的大鼠发情期持续时间更长，表明它们的发情周期被打乱了。由于DHEA处理大鼠血清促黄体生成素水平和下丘脑Kiss1 mRNA表达水平降低，子宫重量增加，DHEA和/或雌激素可能直接影响生殖表型。在以往的研究中，DHEA治疗导致慢性睾酮治疗模型的体重和身体组成发生变化，但在本研究中没有发现这种变化。
Abstract The neonatal and/or prepubertal androgen milieu affects sexual maturation and reproductive function in adulthood. However, the effects of chronic dehydroepiandrosterone (DHEA) treatment on reproductive functions have not been fully elucidated. Therefore, the reproductive phenotypes and parameters of rats that had been subjected to chronic DHEA treatment were evaluated in this study. The chronic DHEA-treated (from postnatal day 23–12 weeks of age) rats exhibited earlier vaginal opening, indicating that DHEA treatment promotes sexual maturation. In addition, the estrus phase lasted longer in the DHEA-treated rats, suggesting that their estrous cycles had been disrupted. As the DHEA-treated rats’ serum luteinizing hormone levels and hypothalamic Kiss1 mRNA expression levels were decreased and their uterine weight was increased, DHEA and/or estrogen might directly affect reproductive phenotypes. While DHEA treatment caused changes in body weight and body composition in chronic testosterone-treated models in previous studies, no such changes were seen in the present study.