Facile and stereospecific synthesis of (S)- and (R)-[2-2H]isopentenyl pyrophosphates
Facile and stereospecific synthesis of (S)- and (R)-[2-2H]isopentenyl pyrophosphates
复制标题
(S)-和(R)-[2-2H]异戊烯基焦磷酸的简便立体合成
DOI：
10.1039/p19870002845
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Tatsuya Ohmoto
中科院分区：
文献类型：
--
作者：
T. Suga;S. Ohta;Tatsuya Ohmoto
以3，3-二甲基烯丙醇为起始原料，通过(S)-和(R)-3-甲基-2，3-环氧丁烷-1-醇，分五步合成了(S)-和(R)-[2-2H]异戊烯基焦磷酸，总收率分别为18%和15%。
(S)- and (R)-[2-2H]isopentenyl pyrophosphates, which are useful precursors for stereochemical studies on the biosynthesis of isoprenoids, were chemically synthesized in five steps via(S)- and (R)-3-methyl-2,3-epoxybutan-1-ols starting with 3,3-dimethylallyl alcohol, in 18% and 15% overall yields, respectively.