Cerebral blood flow and dementia in Parkinson's disease.
Cerebral blood flow and dementia in Parkinson's disease.
复制标题
DOI：
10.1177/089198879100400404
复制
发表时间：
1991-10-01
影响因子：
2.6
通讯作者：
Sugita, M
中科院分区：
文献类型：
--
作者：
Kawabata, K;Tachibana, H;Sugita, M
应用单光子发射计算机断层扫描和N-异丙基-p-[123 I]碘苯丙胺作为示踪剂，对27例帕金森病患者进行了局部脑血流量（CBF）检查。他们的CBF模式与7名阿尔茨海默病患者和9名年龄匹配的神经正常对照进行了比较。示踪剂活性测定在7个双边小脑，皮质，皮质下区域，并表示为在每个区域的平均示踪剂活性在小脑区域的活动比。与对照组相比，19例非痴呆性帕金森病患者的额叶和颞叶皮质、基底节和丘脑的示踪剂活性比率显著降低。8例痴呆帕金森病患者的颞叶和顶叶皮质的示踪剂活性比与非痴呆患者相比显著降低，并表现出与阿尔茨海默病患者相似的CBF模式。这些发现表明，在帕金森病患者中，额叶皮质区CBF减少的机制与颞顶皮质区不同，并支持帕金森病和阿尔茨海默病在某些患者中可能重叠的概念。
Regional cerebral blood flow (CBF) was examined in 27 patients with Parkinson's disease using single-photon emission computed tomography and N-isopropyl-p-[123I]iodoamphetamine as a tracer. Their CBF pattern was compared with that of seven patients with Alzheimer's disease and nine age-matched neurologically normal controls. Tracer activity was determined in seven bilateral cerebellar, cortical, and subcortical regions and was expressed as the ratio of activity in each region to the mean tracer activity in the cerebellar region. Nineteen patients with nondemented Parkinson's disease showed significantly decreased tracer activity ratio in the frontal and temporal cortices, basal ganglia, and thalamus compared with that in controls. The eight demented Parkinson's disease patients showed significantly decreased tracer activity ratio in the temporal and parietal cortices compared with the patients without dementia, and demonstrated CBF pattern similar to that of patients with Alzheimer's disease. These findings suggest that in patients with Parkinson's disease, the mechanism of CBF reduction of the frontal cortical region differs from that in the temporoparietal cortical region and support the concept that Parkinson's disease and Alzheimer's disease may overlap in some patients.