Assessment of excess fluid distribution in chronic hemodialysis patients using bioimpedance spectroscopy
Assessment of excess fluid distribution in chronic hemodialysis patients using bioimpedance spectroscopy
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DOI：
10.1038/ki.1996.160
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发表时间：
1996-04-01
影响因子：
19.6
通讯作者：
Spiegel, DM
中科院分区：
文献类型：
--
作者：
Fisch, BJ;Spiegel, DM
血液透析（HD）患者的钠和水稳态异常，然而，过量液体的分布（细胞外与细胞内）尚未完全表征。我们使用生物阻抗谱研究了液体的分布，以确定 HD 患者相对于对照组在任何特定隔室中是否有过量的液体。双能X射线吸收测定法用于测量去脂体重和骨矿物质含量。经过骨矿物质含量 (RI(ECW):BMC) 校正后，HD 前患者的细胞外水容量阻力指数 (RI) (RI(ECW)) 显着增加（HD 前，19.0 +/- 3.3；对照组，15.8 +/- 1.7 cm(2)-ohms(-1)-kg(-1)；P < 0.01）。 HD 后该值下降至控制范围 (15.2 +/- 2.5 cm(2)-ohms(-1)-kg(-1))。对照组和 HD 患者之间的细胞内水量与骨矿物质含量 (RI(ICW):BMC) 没有差异。这些数据表明，血液透析患者的多余液体量主要存在于细胞外室中，生物阻抗谱与骨矿物质含量等瘦组织的稳定测量相结合，可以确定相对过量水合作用的程度。
Sodium and water homeostasis is abnormal in hemodialysis (HD) patients, however, the distribution of the excess fluid (extracellular vs. intracellular) has not been fully characterized. We studied the distribution of fluid using bioimpedance spectroscopy to determine if HD patients have an excess of fluid in any specific compartment relative to controls. Dual-energy x-ray absorptiometry was used to measure lean body mass and bone mineral content. The resistive index (RI) for extracellular water volume (RI(ECW)), was significantly increased in patients pre-HD when corrected for bone mineral content (RI(ECW):BMC) (pre-HD, 19.0 +/- 3.3; controls, 15.8 +/- 1.7 cm(2)-ohms(-1)-kg(-1); P < 0.01). This value decreased to the control range following HD (15.2 +/- 2.5 cm(2)-ohms(-1)-kg(-1)). The intracellular water volume to bone mineral content (RI(ICW):BMC) was not different between controls and HD patients. These data suggest that hemodialysis patients carry their excess fluid volume primarily in the extracellular compartment and that bioimpedance spectroscopy coupled with a stable measure of lean tissue such as bone mineral content can determine the degree of relative excess hydration.