The Hansenula polymorpha PDD7 gene is essential for macropexophagy and microautophagy
The Hansenula polymorpha PDD7 gene is essential for macropexophagy and microautophagy
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DOI：
10.1016/s1567-1356(02)00135-6
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发表时间：
2003-03-01
影响因子：
3.2
通讯作者：
Kiel, JAKW
中科院分区：
文献类型：
--
作者：
Komduur, JA;Veenhuis, M;Kiel, JAKW
多形汉逊酵母PDD基因通过巨噬作用参与过氧化物酶体的选择性降解。我们通过基因标签的方法分离了多种新型pdd突变体。在这里，我们描述了PDD 7的分离和表征，PDD 7编码与酿酒酵母Apg 1 p/Aut 3 p具有高度序列相似性（40%同一性）的蛋白质，先前描述为参与随机自噬和胞质到液泡靶向途径。我们的数据表明，HpPdd 7 p是必不可少的两个过程，降解过氧化物酶体，即高选择性的过程中的macropexophagy和microautophagy，这发生在H。polymorpha在氮饥饿下的生长。(C)2002年，欧洲微生物学会联合会。由Elsevier Science B. V.出版，版权所有。
Hansenula polymorpha PDD genes are involved in the selective degradation of peroxisomes via macropexophagy. We have isolated various novel pdd mutants by a gene-tagging method. Here we describe the isolation and characterisation of PDD7, which encodes a protein with high sequence similarity (40% identity) to Saccharomyces cerevisiae Apg1p/Aut3p, previously described to be involved in random autophagy and the cytoplasm-to-vacuole targeting pathway. Our data indicate that HpPdd7p is essential for two processes that degrade peroxisomes, namely the highly selective process of macropexophagy and microautophagy, which occurs in H. polymorpha upon nitrogen starvation. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.