Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans
Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans
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DOI：
10.1038/ng2116
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发表时间：
2007-10-01
期刊：
影响因子：
30.8
通讯作者：
Reich, David
中科院分区：
文献类型：
--
作者：
Keinan, Alon;Mullikin, James C.;Reich, David
最近已经收集了大量关于人类遗传变异的数据集，但它们对了解历史和自然选择的有用性受到选择多态性方式的偏见的限制。我们报告了来自国际人类基因组单体型图项目的大量SNP子集（1，2），这些SNP子集使我们能够克服这些偏倚，并提供对理解遗传变异至关重要的数量的准确测量：等位基因频率谱。我们的分析表明，东亚和北方欧洲的祖先有着同样的人口瓶颈，从非洲向外扩张，但两者都经历了更近的遗传漂变，东亚人的遗传漂变更大。
Large data sets on human genetic variation have been collected recently, but their usefulness for learning about history and natural selection has been limited by biases in the ways polymorphisms were chosen. We report large subsets of SNPs from the International HapMap Project(1,2) that allow us to overcome these biases and to provide accurate measurement of a quantity of crucial importance for understanding genetic variation: the allele frequency spectrum. Our analysis shows that East Asian and northern European ancestors shared the same population bottleneck expanding out of Africa but that both also experienced more recent genetic drift, which was greater in East Asians.