Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
复制标题
DOI：
10.1021/np049577a
复制
发表时间：
2005-05-01
影响因子：
5.1
通讯作者：
Jung, JH
中科院分区：
文献类型：
--
作者：
Bao, BQ;Sun, QS;Jung, JH
Three new bisindole alkaloids of the hamacanthin class (1-3) and one new bisindole alkaloid of the topsentin class (6) were isolated along with known bisindole alkaloids (4, 5, 7-11) from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR, MS, and IR spectroscopic analyses. Configurations of compounds 1-4 were derived from H-1 NMR data and optical rotation. Compounds 1, 4, 5, and 11 showed moderate to significant cytotoxicity against five human tumor cell lines, and compounds 1-5 showed weak antibacterial activity against clinically isolated methicillin-resistant strains.
