Catalytic enantioselective construction of tetrasubstituted carbons by self-assembled poly rare earth metal complexes.
Catalytic enantioselective construction of tetrasubstituted carbons by self-assembled poly rare earth metal complexes.
复制标题
DOI：
10.1039/b704542e
复制
发表时间：
2007-06
影响因子：
3.2
通讯作者：
M. Shibasaki;M. Kanai
中科院分区：
文献类型：
--
作者：
M. Shibasaki;M. Kanai
开发了一种稀土金属催化剂，可以促进酮和酮亚胺的氰化反应。这些催化的对映选择性四取代碳形成反应是合成生物活性化合物的有用平台。对催化剂的ESI-MS和晶体学研究表明，活性催化剂是通过模块组装产生的多金属配合物。多金属配合物的高级结构对催化剂的活性和对映选择性有很大影响。控制人工多金属不对称催化剂的高阶结构是优化不对称催化剂的一种新策略。最近的进展，这种方法也被描述。
Rare earth metal-based enantioselective catalysts that can promote practical cyanation reactions of ketones and ketoimines were developed. These catalytic enantioselective tetrasubstituted carbon-forming reactions are useful platforms for the synthesis of biologically active compounds. ESI-MS and crystallographic studies of the asymmetric catalysts revealed that the active catalysts are polymetallic complexes produced through the assembly of modules. The higher-order structure of the polymetallic complexes has strong effects on catalyst activity and enantioselectivity. Controlling the higher-order structure of artificial polymetallic asymmetric catalysts is a new strategy for optimizing asymmetric catalysts. Recent progress in this approach is also described.