PROPOSAL FOR THE REGULATORY MECHANISM OF WOLFFS LAW
PROPOSAL FOR THE REGULATORY MECHANISM OF WOLFFS LAW
复制标题
DOI：
10.1002/jor.1100130405
复制
发表时间：
1995-07-01
影响因子：
2.8
通讯作者：
HUISKES, R
中科院分区：
文献类型：
--
作者：
MULLENDER, MG;HUISKES, R
目前认为骨小梁结构是由机械载荷控制的动态重塑过程的结果。我们提出了一种基于骨内骨细胞感知机械信号的调节机制，这些细胞介导其附近的破骨细胞和成骨细胞来适应骨量。基于这些假设的计算机模拟模型被用来研究现实中观察到的Wolff定律意义上的骨适应和重塑现象是否可以用这种局部控制过程来解释。该模型产生的结构类似于实际的小梁结构。根据Wolff的轨迹假设，改变外部载荷后，结构发生了变化，使小梁与实际主应力方向对齐。实际上，结构的相对表观密度取决于外加应力的大小。骨细胞密度影响骨重塑率，这与实验结果一致。此外，结果表明，骨细胞的影响域影响结构的细化，如支柱的分离和厚度。我们的结论是，正如Wolff所描述的那样，小梁对机械负荷的适应可以用一个相对简单的调节模型来解释。该模型可用于研究生理参数对骨发育、维持和适应的影响。
It is currently believed that the trabecular structure in bone is the result of a dynamic remodeling process controlled by mechanical loads. We propose a regulatory mechanism based on the hypothesis that osteocytes located within the bone sense mechanical signals and that these cells mediate osteoclasts and osteoblasts in their vicinity to adapt bone mass. A computer-simulation model based on these assumptions was used to investigate if the adaptation of bone, in the sense of Wolff's law, and remodeling phenomena, as observed in reality, can be explained by such a local control process. The model produced structures resembling actual trabecular architectures. The architecture transformed after the external loads were changed, aligning the trabeculae with the actual principal stress orientation, in accordance with Wolff's trajectorial hypothesis. As in reality, the relative apparent density of the structure depended on the magnitude of the applied stresses. Osteocyte density influenced the remodeling rate, which also is consistent with experimental findings. Furthermore, the results indicated that the domain of influence of the osteocytes affects the refinement of the structure as represented by separation and thickness of the struts. We concluded that the trabecular adaptation to mechanical load, as described by Wolff, can be explained by a relatively simple regulatory model. The model is useful for investigating the effects of physiological parameters on the development, maintenance, and adaptation of bone.