A follow-up study of morbidity and mortality associated with hepatitis C virus infection and its interaction with human T lymphotropic virus type I in Miyazaki, Japan
A follow-up study of morbidity and mortality associated with hepatitis C virus infection and its interaction with human T lymphotropic virus type I in Miyazaki, Japan
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DOI：
10.1086/315177
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发表时间：
2000-01-01
影响因子：
6.4
通讯作者：
Mueller, N
中科院分区：
文献类型：
--
作者：
Boschi-Pinto, C;Stuver, S;Mueller, N
为了分析丙型肝炎病毒(丙型肝炎病毒)感染对成年人群发病率和死亡率的影响，对日本一个既有丙型肝炎病毒流行水平又有人类T淋巴细胞趋化病毒I型(HTLV-I)的村庄进行了随访研究。采用COX比例风险模型，估计了比率比(RR)和95%可信区间(CI)。丙型肝炎病毒抗体阳性对自身报告的肝病(RR，3.5；95%CI，1.9-6.4)和肝癌死亡(RR，8.2；95%CI，1.6-41.4)有显著的影响。丙型肝炎病毒和HTLV-I双重感染似乎对肝病(RR，5.9)和肝癌死亡(RR，21.9)有协同作用。丙型肝炎病毒感染也与报告的糖尿病发病呈正相关，尽管不显著。我们的发现表明，与HTLV-I混合感染可能影响丙型肝炎病毒相关疾病的病程。
A follow-up study was performed to analyze the effects of hepatitis C virus (HCV) infection on morbidity and mortality in the adult population from a village in Japan found to have endemic levels of both HCV and human T lymphotropic virus type I (HTLV-I), By use of the Cox proportional hazards model, rate ratios (RRs) and 95% confidence intervals (CIs) were estimated. Strong, significant effects of seropositivity for antibodies to HCV on self-reported incident liver disease (RR, 3.5; 95% CI, 1.9-6.4) and on death due to liver cancer (RR, 8.2; 95% CI, 1.6-41.4) were observed, Dual infection with HCV and HTLV-I seemed to have a synergistic effect on incident liver disease (RR, 5.9) as well as on death from liver cancer (RR, 21.9). HCV infection also was positively, although not significantly, associated with reported incident diabetes. Our findings suggest that coinfection with HTLV-I may affect the course of HCV-associated disease.