Seasonal variation in platelet [H-3]paroxetine binding in healthy volunteers - Relationship to climatic variables
Seasonal variation in platelet [H-3]paroxetine binding in healthy volunteers - Relationship to climatic variables
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DOI：
10.1016/0893-133x(95)00183-e
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发表时间：
1996-08-01
影响因子：
7.6
通讯作者：
Desnyder, R
中科院分区：
文献类型：
--
作者：
DHondt, P;Maes, M;Desnyder, R
最近，我们的实验室报道了抑郁症患者中[H-3]帕罗西汀与血小板结合的显著季节性差异。本研究旨在研究[H-3]帕罗西汀与血小板结合的季节性变化，以及[H-3]帕罗西汀与健康志愿者气候变量之间的关系。我们每月采集26名健康志愿者的血液样本进行[H-3]帕罗西汀结合测定，并通过单变量和多变量光谱和余弦分析对数据进行分析。[3H]帕罗西汀与血小板的结合具有统计学上高度显著的季节性规律，具有显著的年、4月、2月节律，表现为群体现象。[H-3]帕罗西汀与血小板的结合在秋季和夏季显著低于冬季和春季；夏季低，春季高。这种年度变化的峰谷差异，以平均值的百分比表示，高达83.7%。[H-3]帕罗西汀结合的很大一部分差异，即32.5%，可以用天气变量来解释，如环境温度、相对湿度和气压。在[H-3]帕罗西汀结合和环境温度或湿度（两者呈负相关）以及采血前2周的温度变化（正相关）中表达了高度显著的常见年度节律。
Recently, our laboratory has reported significant seasonal differences in [H-3]paroxetine binding to platelets in depressed subjects. This study aimed to examine the seasonal variation in [H-3]paroxetine binding to platelets and the relationships between [H-3]paroxetine binding and climatic variables in healthy volunteers. We took monthly blood samples during one calendar year from 26 healthy volunteers for assay of [H-3]paroxetine binding and analyzed the data by means of univariate and multivariate spectral and cosinor analyses. There was a statistically highly significant seasonal pattern in [3H]paroxetine binding to platelets with significant annual, 4-monthly and bimonthly rhythms, which were expressed as a group phenomenon. [H-3]paroxetine binding to platelets was significantly lower in fall and summer than in winter and spring; lows occurred in summer and peaks in spring. The peak-trough difference in this yearly variation, expressed as a percentage of the mean, was as large as 83.7%. A large part of the variance, that is, 32.5%, in [H-3]paroxetine binding could be explained by weather variables, such as ambient temperature, relative humidity and air pressure. Highly significant common annual rhythms were expressed in [H-3]paroxetine binding and ambient temperature or humidity (both inversely related) and changes in temperature the 2 weeks preceding blood samplings (positively related).