Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome
Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome
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DOI：
10.1016/j.lfs.2006.08.007
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发表时间：
2006-11-25
期刊：
影响因子：
6.1
通讯作者：
Kunitomo, Masaru
中科院分区：
文献类型：
--
作者：
Yamaguchi, Yu;Yamada, Kotaro;Kunitomo, Masaru
科罗索酸（Corosolic acid，CRA）是巴拿巴叶的一种成分，具有抗炎和降血糖的作用。本研究的目的是确定CRA对代谢危险因素的影响，包括肥胖、高血压、高胰岛素血症、高血糖和高脂血症以及氧化应激和炎症，所有这些都是代谢综合征动物模型SHR/NDmcr-cp（cp/cp）（SHR-cp）大鼠的特征。6周龄雄性SHR-cp大鼠饲喂含0.072%CRA的高脂饲料14周。用CRA治疗降低血压，其在对照动物中升高，8周后降低10%，2周后血清游离脂肪酸降低21%。CRA治疗导致氧化应激标志物硫代巴比妥酸反应物质和8-羟基脱氧鸟苷的水平在2周后分别下降了27%和59%。CRA治疗10周后还使髓过氧化物酶标记物3-硝基酪氨酸和3-氯酪氨酸的水平分别降低了38%和39%，并在6周后倾向于降低高敏C反应蛋白（炎症标记物）的水平。然而，CRA对体重增加或高血糖没有影响。这些结果表明，CRA可以改善SHR-cp大鼠的高血压、脂质代谢异常、氧化应激以及炎症状态。这意味着MA可以有益于预防动脉粥样硬化相关疾病，这是一个日益严重的全球卫生保健问题。(c)2006年爱思唯尔公司All rights reserved.
Corosolic acid (CRA), a constituent of banaba leaves, has been reported to have anti-inflammatory and hypoglycemic activities. The aim of this study was to determine the effects of CRA on metabolic risk factors including obesity, hypertension, hyperinsulinemia, hyperglycemia, and hyperlipidemia together with oxidative stress and inflammation, all of which are characteristic of the SHR/NDmcr-cp (cp/cp) (SHR-cp) rat, an animal model of metabolic syndrome. Six-week-old male SHR-cp rats were fed a high fat diet containing 0.072% CRA for 14 weeks. Treatment with CRA lowered blood pressure, which was elevated in control animals, by 10% after 8 weeks, and serum free fatty acids by 2 1 % after 2 weeks. CRA treatment resulted in decreases in the levels of the oxidative stress markers thiobarbituric acid-reactive substances and 8-hydroxydeoxyguanosine by 27% and 59%, respectively, after 2 weeks. CRA treatment also reduced the levels of myeloperoxidase markers, 3-nitrotyrosine and 3-chlorotyrosine by 38% and 39%, respectively, after 10 weeks, and tended to decrease the levels of high sensitivity C-reactive protein, a marker of inflammation, after 6 weeks. However, CRA had no effect on weight gain or hyperglycemia. These results demonstrate that CRA can ameliorate hypertension, abnormal lipid metabolism, and oxidative stress as well as the inflammatory state in SHR-cp rats. This implies that MA can be beneficial for preventing atherosclerosis-related diseases that are an increasing health care problem worldwide. (c) 2006 Elsevier Inc. All rights reserved.